Pitavastatin (Calcium)

CAT#: H318503

CAS#: 147511-69-1 / 147526-32-7

Description: Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187.

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Synthetic Routes

Pitavastatin (Calcium) - Synthetic Route 1

Pitavastatin (Calcium) route01

Synthetic reference

Yagi, Yusuke; Kimura, Hiroyuki; Arimitsu, Kenji; Ono, Masahiro; Maeda, Kazuya; Kusuhara, Hiroyuki; Kajimoto, Tetsuya; Sugiyama, Yuichi; Saji, Hideo. The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling. Organic & Biomolecular Chemistry. Volume 13. Issue 4. Pages 1113-1121. 2015.

Pitavastatin (Calcium) - Synthetic Route 2

Pitavastatin (Calcium) route02

Synthetic reference

Reddy, Manne Satyanarayana; Eswaraiah, Sajja; Reddy, Maramreddy Sahadeva. Improved process for the preparation of highly pure pitavastatin and its pharmaceutically acceptable salts. Assignee MSN Laboratories Ltd., India. IN 2009CH00120. (2010).

Pitavastatin (Calcium) - Synthetic Route 3

Pitavastatin (Calcium) route03

Synthetic reference

Nishino, Shigeyoshi; Yokoyama, Shuji; Kawachi, Yasuhiro; Sasaki, Hiroshi. Process for producing (3R,5S)-7-substituted-3,5-dihydroxyhept-6-enoic acid. Assignee Ube Industries, Ltd., Japan. WO 2002092570. (2002).

Pitavastatin (Calcium) - Synthetic Route 4

Pitavastatin (Calcium) route04

Synthetic reference

Taddei, Maurizio; Balducci, Evita; Attolino, Emanuele; Mantegazza, Simone; Dell'anna, Gianmaria. Process for the preparation of statins. Assignee Dipharma Francis S.r.l., Italy. EP 2383260. (2011).

Pitavastatin (Calcium) - Synthetic Route 5

Pitavastatin (Calcium) route05

Synthetic reference

Hwang, Seong Gwan; Lee, Su Jin. Method for preparation of pitavastatin intermediate and pitavastatin hemi-calcium salt. Assignee Mirae Fine Chem Co., Ltd., S. Korea. KR 2010052230. (2010).

Pitavastatin (Calcium) - Synthetic Route 6

Pitavastatin (Calcium) route06

Synthetic reference

Wang, Bing; Li, Zebiao; Ding, Haiming; Miao, Pei. Method for preparing pitavastatin calcium intermediates. Assignee Nantong Changyou Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 104016916. (2014).

Pitavastatin (Calcium) - Synthetic Route 7

Pitavastatin (Calcium) route07

Synthetic reference

Zhu, Jianrong; Jin, Zhiping; Hua, Changhua; Chen, Jianyang. Intermediate used for preparing dihydroxy acid hydroxymethyl glutaryl coenzyme A reductase inhibitor, its preparation, and application. Assignee Zhejiang Jingxin Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103288871. (2013).

Pitavastatin (Calcium) - Synthetic Route 8

Pitavastatin (Calcium) route08

Synthetic reference

Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Samala Malla; Krishna, Bandi Vamsi. Novel polymorphs of pitavastatin calcium. Assignee Hetero Research Foundation, India. IN 2010CH03399. (2012).

Pitavastatin (Calcium) - Synthetic Route 9

Pitavastatin (Calcium) route09

Synthetic reference

Sethi, Madhuresh Kumar; Mahajan, Sanjay; Rawat, Vijendra Singh; Mara, Bhairaiah; Veera, Upendra Nath; Datta, Debashish. improved process for the preparation of hmg-coa reductase inhibitor intermediates. Assignee Matrix Laboratories Ltd., India. WO 2011141934. (2011).

Pitavastatin (Calcium) - Synthetic Route 10

Pitavastatin (Calcium) route010

Synthetic reference

Ramanathan, Mani; Liu, Shiuh-Tzung. Cascade annulations of aryldiazonium salts, nitriles and halo-alkynes leading to 3-haloquinolines. Tetrahedron. Volume 73. Issue 30. Pages 4317-4322. 2017.