Lomitapide

CAT#: H319516

CAS#: 182431-12-5

Description: Lomitapide is a MTP inhibitor. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.

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Synthetic Routes

Lomitapide - Synthetic Route 1

Lomitapide route01

Synthetic reference

Vadali, Lakshmana Rao; Yerva, Eswara Reddy; Vemavarapu, Govardhana Phani Sharma. Process for preparation of lomitapide mesylate. Assignee Mylan Laboratories Ltd., India. IN 2014CH03561. (2016).

Lomitapide - Synthetic Route 2

Lomitapide route02

Synthetic reference

Thirumalai Rajan, Srinivasan; Nagaraju, Chakilam; Eswaraiah, Sajja; Venkat Reddy, Ghojala; Kodanda Ramprasad, Achampeta; Rajesham, Boge; Adilakshmi, Singavarapu. Preparation of crystalline polymorph of N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate. Assignee MSN Laboratories Private Limited, India. WO 2017098522. (2018).

Lomitapide - Synthetic Route 3

Lomitapide route03

Synthetic reference

Bhirud, Shekhar Bhaskar; Naik, Samir; Mishra, Sushanta; Pandey, Vipin; Patekar, Deepak S. Process for the preparation of the amorphous form of lomitapide mesylate. Assignee Glenmark Pharmaceuticals Ltd., India. IN 2014MU03209. (2016).

Lomitapide - Synthetic Route 4

Lomitapide route04

Synthetic reference

Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Krishna, Bandi Vamsi; Reddy, Jambula Mukunda. Process for the preparation of Lomitapide. WO 2016071849. Assignee Hetero Research Foundation, India. WO 2016071849. (2016).