Prasugrel

CAT#: H315263

CAS#: 150322-43-3

Description: Prasugrel (marketing name Effient in the US, Efient in the EU and Prasita in India) is a novel platelet inhibitor developed by Daiichi Sankyo Co. and produced by Ube and currently marketed in the United States in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary intervention (PCI). Prasugrel was approved for use in Europe in February 2009, and is currently available in the UK. On July 10, 2009, the US Food and Drug Administration approved the use of prasugrel for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI.

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Synthetic Routes

Prasugrel - Synthetic Route 1

Prasugrel route01

Synthetic reference

Padi, Pratap Reddy; Peri, Seetha Rama Sarma; Ganta, Madhusudhan Reddy; Polavarapu, Srinivas; Cherukupally, Praveen; Ireni, Babu; Padamata, Shailaja; Jonnada, Krishna; Vinigari, Krishna; Nerella, Kavitha. A process for preparing prasugrel and its salts and polymorphs. Assignee Dr. Reddy's Laboratories Ltd., India; Dr. Reddy's Laboratories, Inc. WO 2009062044. (2009).

Prasugrel - Synthetic Route 2

Prasugrel route02

Synthetic reference

Reddy, Manne Satyanarayana; Eswaraiah, Sajja; Reddy, Ghojala Venkat. Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts. Assignee MSN Laboratories Limited, India. IN 292121. (2018).

Prasugrel - Synthetic Route 3

Prasugrel route03

Synthetic reference

Ou, Wenhua; Yi, Weiyin; Liu, Feng; Pan, Xianhua; Peng, Xijiang. An improvement to the preparation of prasugrel hydrochloride. Journal of Chemical Research. Volume 37. Issue 6. Pages 369-371. 2013.

Prasugrel - Synthetic Route 4

Prasugrel route04

Synthetic reference

Rao, A. v. v. Srinivas; Jaware, Jalindar; Goud, Srinivas; Bijukumar, Gopinathan Pillai; Nadkarni, Sunil Sadanand. Process for the preparation of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine. Assignee Torrent Pharmaceuticals Ltd., India. WO 2009122440. (2009).

Prasugrel - Synthetic Route 5

Prasugrel route05

Synthetic reference

Ahmed, Khan Mubeen; Sanikommu, Srinivas Reddy; Antyakula Pydi, Bhaskar Rao; Sanganabhatla, Shankar. Preparation of prasugrel and its hydrochloride salt and crystal forms. Assignee Glenmark Generics Limited, India. WO 2010070677. (2010).

Prasugrel - Synthetic Route 6

Prasugrel route06

Synthetic reference

Stepankova, Hana; Hajicek, Josef. Process for the manufacturing of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel). Assignee Zentiva A.S., Czech Rep. WO 2009006859. (2009).

Prasugrel - Synthetic Route 7

Prasugrel route07

Synthetic reference

Satyanarayana Reddy, Manne; Thirumalai Rajan, Srinivasan; Eswaraiah, Sajja; Reddy, Karamala Rama Subba; Kondal Reddy, Bairy; Reddy, Ghojala Venkat. Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts. Assignee MSN Laboratories Limited, India. WO 2011042918. (2011).

Prasugrel - Synthetic Route 8

Prasugrel route08

Synthetic reference

Zhao, Zhiquan; Bai, Wenqin. Preparation of prasugrel and its salts as platelet aggregation inhibitors. Assignee Lunan Pharmaceutical Group Corporation, Peop. Rep. China. CN 101177430. (2008).

Prasugrel - Synthetic Route 9

Prasugrel route09

Synthetic reference

Ou, Wenhua; Yi, Weiyin; Liu, Feng; Pan, Xianhua; Peng, Xijiang. An improvement to the preparation of prasugrel hydrochloride. Journal of Chemical Research. Volume 37. Issue 6. Pages 369-371. 2013.

Prasugrel - Synthetic Route 10

Prasugrel route010

Synthetic reference

Thijs, Lambertus; Zhu, Jie; Overeem, Arjanne; Keltjens, Rolf. A process for making prasugrel. Assignee Synthon BV, Neth. WO 2011110219. (2011).