Mirabegron

CAT#: H314233

CAS#: 223673-61-8

Description: Mirabegron (formerly YM-178, trade name Myrbetriq) is a drug for the treatment of overactive bladder. It was developed by Astellas Pharma and was approved in the United States in July 2012. Mirabegron activates the β3 adrenergic receptor in the detrusor muscle in the bladder, which leads to muscle relaxation and an increase in bladder capacity.

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Synthetic Routes

Mirabegron - Synthetic Route 1

Mirabegron route01

Synthetic reference

Vedantham, Ravindra; Kandagatla, Bhaskar; Vyala, Sunitha; Raju, V. V. N. K. V. Prasada; Cherukupalli, Praveen; Iqbal, Javed; Dahanukar, Vilas H.; Kagga, Mukkanti; Bandichhor, Rakeshwar; Oruganti, Srinivas. Practical synthesis of Mirabegron. Journal of Chemical and Pharmaceutical Research. Volume 7. Issue 4. Pages 1473-1478. Journal; Online Computer File. (2015).

Mirabegron - Synthetic Route 2

Mirabegron route02

Synthetic reference

Xu, Guiqing; Mao, Shen; Mao, Longfei; Jiang, Yuqin; Zhou, Yong; Shen, Jiaxuan; Dong, Wenpei. Study on a New Method for Synthesis of Mirabegron. Journal of Heterocyclic Chemistry. Volume 54. Issue 5. Pages 2703-2707. Journal; Online Computer File. (2017).

Mirabegron - Synthetic Route 3

Mirabegron route03

Synthetic reference

De Angelis, Sonia; Carlucci, Claudia; de Candia, Modesto; Rebuzzini, Gabriele; Celestini, Paolo; Riscazzi, Massimiliano; Luisi, Renzo; Degennaro, Leonardo. Targeting a Mirabegron precursor by BH3-​mediated continuous flow reduction process. Catalysis Today. Volume 308. Pages 81-85. Journal; Online Computer File. (2018).

Mirabegron - Synthetic Route 4

Mirabegron route04

Synthetic reference

Zhang, Lei; Tan, Zhimin; Jiao, Huirong; Qiu, Pengcheng; Zhang, Fuli. Synthesis of related substance of mirabegron. Zhongguo Yiyao Gongye Zazhi. Volume 45. Issue 1. Pages 9-12. Journal. (2014).

Mirabegron - Synthetic Route 5

Mirabegron route05

Synthetic reference

: Jung, In Hwa; Lee, In Gyu; Mo, Gil Ung; Han, Hae Su; Han, Ga Ram; Shin, Jae Won; Kim, Hyeon Jeong; Kim, A. Reum; Jung, Gi Won; Ahn, Ji Hun. Preparation of salts of amide derivatives. Assignee Sungwun Pharmacopia Co., Ltd., S. Korea. KR 2018138058. (2018).

Mirabegron - Synthetic Route 6

Mirabegron route06

Synthetic reference

Shankar, Rama; Chavhan, Bhausaheb; Tummalapalli, Umasankara Sastry; Talatala, Appi Reddy; Pareddi, Gandhi. An improved process for the preparation of Mirabegron. Assignee Mylan Laboratories Ltd., India. IN 2013CH02517. (2016).

Mirabegron - Synthetic Route 7

Mirabegron route07

Synthetic reference

Pradhan, Nitin Sharadchandra; Patil, Nilesh Sudhir; Walavalkar, Rajesh Ramchandra; Kulkarni, Nilesh Subhash; Rawool, Santosh Namdev; Awate, Purushottam Ekanath. A process for the preparation of mirabegron and its intermediates. Assignee Wanbury Ltd., India. IN 2014MU02534. (2016).

Mirabegron - Synthetic Route 8

Mirabegron route08

Synthetic reference

Li, Wei; Mao, Shen; Mao, Longfei; Jiang, Yuqin; Zhang, Yingui; Yuan, Lishuang; Xu, Guiqing; Dong, Wenpei; Jiang, Tao. Process for the preparation of mirabegron. Assignee Henan Normal University, Peop. Rep. China. CN 105111165. (2015).

Mirabegron - Synthetic Route 9

Mirabegron route09

Synthetic reference

Hu, Fan; Wang, Shenyong; Jia, Xinzan; Wang, Xiaojun; Hu, Junkai. Process for synthesis of Mirabegron. Assignee Suzhou Uugene Biopharma Co., Ltd., Peop. Rep. China. CN 103193730. (2013).