Olodaterol

CAT#: H314250

CAS#: 868049-49-4

Description: Olodaterol, also known as BI 1744, is a long acting beta-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD), manufactured by Boehringer-Ingelheim. Olodaterol was approved by FDA in 2014 for the treatment of chronic obstructive pulmonary disease.

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Synthetic Routes

Olodaterol - Synthetic Route 1

Olodaterol route01

Synthetic reference

Bouyssou, Thierry; Hoenke, Christoph; Rudolf, Klaus; Lustenberger, Philipp; Pestel, Sabine; Sieger, Peter; Lotz, Ralf; Heine, Claudia; Buettner, Frank H.; Schnapp, Andreas; Konetzki, Ingo. Discovery of olodaterol, a novel inhaled β2-​adrenoceptor agonist with a 24h bronchodilatory efficacy. Bioorganic & Medicinal Chemistry Letters. Volume 20. Issue 4. Pages 1410-1414. Journal. (2010).

Olodaterol - Synthetic Route 2

Olodaterol route02

Synthetic reference

Tian, Miao; Xie, Xue-xing; Ma, Lu; Shen, Xue-yan; Chen, Chang-qing. A new generation of inhaled long-​acting β2-​adrenoceptor agonist olodaterol. Xiandai Yaowu Yu Linchuang. Volume 28. Issue 2. Pages 227-231. Journal; General Review. (2013).

Olodaterol - Synthetic Route 3

Olodaterol route03

Synthetic reference

Yu, Xiong; Zhang, Yuanwei; Yuan, Xilun. Crystal form C of Olodaterol hydrochloride and its preparation method. Assignee Shanghai Front Health Pharmaceutical Technology Co., Ltd., Peop. Rep. China; Joincare Pharmaceutical Industry Group Co., Ltd. CN 108822054. (2018).