Regadenoson

CAT#: H318655

CAS#: 313348-27-5

Description: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing. It produces hyperemia quickly and maintains it for a duration that is useful for radionuclide myocardial perfusion imaging. The selective nature of the drug makes it preferable to other stress agents such as adenosine, which are less selective and therefore cause more side-effects.

img

Synthetic Routes

Regadenoson - Synthetic Route 1

Regadenoson route01

Synthetic reference

Gao, Xihui; Qian, Jun; Zheng, Shuyan; Changyi, Yinzhi; Zhang, Jianping; Ju, Shenghong; Zhu, Jianhua; Li, Cong. Overcoming the Blood-Brain Barrier for Delivering Drugs into the Brain by Using Adenosine Receptor Nanoagonist. ACS Nano. Volume 8. Issue 4. Pages 3678-3689. 2014.

Regadenoson - Synthetic Route 2

Regadenoson route02

Synthetic reference

Zablocki, Jeff; Elzein, Elfatih. Process for preparing an A2a-adenosine receptor agonist and its polymorphs. Assignee Cv Therapeutics, Inc., USA. WO 2008143667. (2008).

Regadenoson - Synthetic Route 3

Regadenoson route03

Synthetic reference

Kovi, Ravishanker; Kannapan, Jayaraman; Thirunavakarasu, Ananda Babu; Fadadu, Piyush D.; Thumar, Piyush B. Novel polymorph of regadenoson and process for preparation thereof. Assignee Apicore US LLC, USA. US 20180127452. (2018).

Regadenoson - Synthetic Route 4

Regadenoson route04

Synthetic reference

Rangisetty, Jagadeesh Babu; Pullagurla, Manik Reddy; Nandakumar, Mecheril Valsan; Naidu, Dokula Neelam. Process for the preparation of a novel polymorph of regadenoson. Assignee Biophore India Pharmaceuticals Pvt. Ltd., India. IN 2013CH02262. (2014).

Regadenoson - Synthetic Route 5

Regadenoson route05

Synthetic reference

Grisenti, Paride; Shahrzad Reza, Elahi; Guazzi, Giuseppe; Argese, Maria. Stable solid forms of regadenoson. Assignee Euticals S.p.A., Italy. EP 2789624. (2014).

Regadenoson - Synthetic Route 6

Regadenoson route06

Synthetic reference

Pullagurla, Manik Reddy; Rangisetty, Jagadeesh Babu; Nandakumar, Mecheril Valsan. Novel process for the preparation of (1-{9-[(4s,2r,3r,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazole-4-yl)-n-methylcarboxamide. Assignee Biophore India Pharmaceuticals Pvt. Ltd., India. IN 2012CH04486. (2016).

Regadenoson - Synthetic Route 7

Regadenoson route07

Synthetic reference

Liu, Wei; Zhang, Zhigang; Ren, Zhen. Process for preparation of Regadenoson. Assignee Shanghai Ziyuan Pharmaceutical Co., Ltd., Peop. Rep. China. CN 104744540. (2015).

Regadenoson - Synthetic Route 8

Regadenoson route08

Synthetic reference

Zhang, Xiaoheng; Mei, Lijun. A process for the preparation of regadenoson. Assignee ScinoPharm Taiwan, Ltd., Peop. Rep. China; ScinoPharm Singapore Pte, Ltd. WO 2015085497. (2015).

Regadenoson - Synthetic Route 9

Regadenoson route09

Synthetic reference

Chai, Jian; Luo, Hairong; Gu, Rongling; Zeng, Shuping; Li, Jiang; Ma, Jing. Novel regadenoson intermediates, their preparation method and application. Assignee Zhejiang Hisun Pharmaceutical Co., Ltd., Peop. Rep. China. CN 104513241. (2015).

Regadenoson - Synthetic Route 10

Regadenoson route010

Synthetic reference

Luo, Hairong; Chai, Jian; Gu, Rongling; Yu, Xufeng. Synthesis of regadenoson. Zhongguo Yiyao Gongye Zazhi. Volume 45. Issue 8. Pages 705-707. 2014.