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Omacetaxine mepesuccinate

CAT#: H317994

CAS#: 26833-87-4

Description: Homoharringtonine, or Omacetaxine mepesuccinate, is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid leukemia (CML). It is a natural product first discovered in Cephalotaxus harringtonia, now manufactured by hemi-synthesis. It was approved by the US FDA in October 2012 for the treatment of adult patients with CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKIs).

Synthetic Routes

Omacetaxine mepesuccinate - Synthetic Route 1

Synthetic reference

Ma, Guo-Zhen; Li, Peng-Fei; Liu, Lu; Li, Wei-Dong Z.; Chen, Li. Diastereoselective Synthesis of Cephalotaxus Esters via Asymmetric Mukaiyama Aldol Reaction. Organic Letters. Volume 19. Issue 9. Pages 2250-2253. Journal; Online Computer File. (2017).

Omacetaxine mepesuccinate - Synthetic Route 2

Synthetic reference

Eckelbarger, Joseph D.; Wilmot, Jeremy T.; Epperson, Matthew T.; Thakur, Chandar S.; Shum, David; Antczak, Christophe; Tarassishin, Leonid; Djaballah, Hakim; Gin, David Y. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry - A European Journal. Volume 14. Issue 14. Pages 4293-4306. Journal. (2008).

Omacetaxine mepesuccinate - Synthetic Route 3

Synthetic reference

Ju, Xuan; Beaudry, Christopher M. Total Synthesis of (-)-Cephalotaxine and (-)-Homoharringtonine via Furan Oxidation-Transannular Mannich Cyclization. Angewandte Chemie, International Edition. Volume 58. Issue 20. Pages 6752-6755. Journal; Online Computer File. (2019).

Omacetaxine mepesuccinate - Synthetic Route 4

Synthetic reference

Wang, Yongkeng; Li, Yulin; Pan, Xinfu; Li, Shaobai; Huang, Wenkui. Synthesis of homoharringtonine and separation of its stereomers. Huaxue Xuebao. Volume 43. Issue 2. Pages 161-7. Journal. (1985).

Omacetaxine mepesuccinate - Synthetic Route 5

Synthetic reference

Herr, Robert Jason; Gregg, Brian Thomas; Geiss, William Bert. Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. Assignee Albany Molecular Research, Inc., USA. WO 2016182850. (2016).

Omacetaxine mepesuccinate - Synthetic Route 6

Synthetic reference

Chen, Li; Li, Weidong. Method for high-efficiency and high-stereoselectivity semisynthesis of Harringtonine-like alkaloid and its medical application. Chen, Li; Li, Weidong. Assignee Nankai University, Peop. Rep. China. CN 102304132. (2012).