Perampanel

CAT#: H314235

CAS#: 380917-97-5

Description: Perampanel is discontinued (DEA controlled substance). Perampanel is a selective noncompetitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors. Perampanel was found to be effective in the treatment of refractory partial-onset seizures in clinical trials.

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Synthetic Routes

Perampanel - Synthetic Route 1

Perampanel route01

Synthetic reference

: Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro. Discovery of 2-​(2-​Oxo-​1-​phenyl-​5-​pyridin-​2-​yl-​1,​2-​dihydropyridin-​3-​yl)​benzonitrile (Perampanel)​: A Novel, Noncompetitive α-​Amino-​3-​hydroxy-​5-​methyl-​4-​isoxazolepropanoic Acid (AMPA) Receptor Antagonist. Journal of Medicinal Chemistry. Volume 55. Issue 23. Pages 10584-10600. Journal; Online Computer File. (2012).

Perampanel - Synthetic Route 2

Perampanel route02

Synthetic reference

McElhinny, Charles J., Jr.; Carroll, F. I.; Lewin, Anita H. A practical, laboratory-​scale synthesis of perampanel. Synthesis. Volume 44. Issue 1. Pages 57-62. Journal. (2012).

Perampanel - Synthetic Route 3

Perampanel route03

Synthetic reference

Lee, Hong Geun; Milner, Phillip J.; Placzek, Michael S.; Buchwald, Stephen L.; Hooker, Jacob M. Virtually Instantaneous, Room-​Temperature [11C]​-​Cyanation Using Biaryl Phosphine Pd(0) Complexes. Journal of the American Chemical Society. Volume 137. Issue 2. Pages 648-651. Journal; Online Computer File. (2015).

Perampanel - Synthetic Route 4

Perampanel route04

Synthetic reference

Dahanukar, Vilas Hareshwar; Iqbal, Javed; Oruganti, Srinivas; Rapolu, Rajesh Kumar. Preparation of perampanel. Assignee Dr. Reddys Laboratories Limited, India. IN 2013CH02042. (2016).

Perampanel - Synthetic Route 5

Perampanel route05

Synthetic reference

Kapkoti, Gobind Singh; Lourdusamy, Mettilda; Radu, Ioan Iosif; Pandya, Ashesh Kamalnayan; Chauhan, Nitesh Dolatram; Dholariya, Bipinkumar Hashmukhbhai; Patel, Vishal Keshavlal. Novel process for the preparation of perampanel and its intermediates thereof. Assignee Intas Pharmaceuticals Ltd., India. WO 2016147104. (2016).

Perampanel - Synthetic Route 6

Perampanel route06

Synthetic reference

: Marom, Ehud; Rubnov, Shai. Process and intermediates for the preparation of perampanel. Assignee Mapi Pharma Ltd., Israel. WO 2016132343. (2016).

Perampanel - Synthetic Route 7

Perampanel route07

Synthetic reference

Desai, Sanjay Jagdish; Parihar, Jayprakash Ajitsingh; Jain, Kuldeep Natwarlal; Patil, Sachin Ashokrao. Process for the preparation of perampanel. Assignee Cadila Healthcare Limited, India. US 20160039759. (2016).

Perampanel - Synthetic Route 8

Perampanel route08

Synthetic reference

Buchlovic, Marian. Process for the preparation of perampanel. Assignee Ivax International GmbH, Switz.; Teva Pharmaceuticals USA, Inc. WO 2015013520. (2015).

Perampanel - Synthetic Route 9

Perampanel route09

Synthetic reference

Ye, Tianjian; Yu, Guangliang; Ma, Suwang. A process for preparing perampanel and its intermediates. Assignee Zhejiang Yongning Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103980188. (2014).

Perampanel - Synthetic Route 10

Perampanel route010

Synthetic reference

Arimoto, Itaru; Nagato, Satoshi; Sugaya, Yukiko; Urawa, Yoshio; Ito, Koichi; Naka, Hiroyuki; Omae, Takao; Kayano, Akio; Nishiura, Katsutoshi. Process for preparation of 1,2-dihydropyridine-2-one derivatives. Assignee Eisai R&D Management Co., Ltd., Japan. US 20070142640. (2007).