Rivaroxaban

CAT#: H300310

CAS#: 366789-02-8

Description: Rivaroxaban, also known as BAY 59-7939, is an oral anticoagulant invented and manufactured by Bayer; in a number of countries it is marketed as Xarelto. If approved by the United States FDA, it will be marketed by Ortho-McNeil Pharmaceutical. It is the first available orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects lasts 8–12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.

img

Synthetic Routes

Rivaroxaban - Synthetic Route 1

Rivaroxaban route01

Synthetic reference

Xu, Xin-liang; Li, Chao; Zhang, Xing-xian. Novel method for synthesis of anticoagulation drug rivaroxaban. Zhongguo Yaowu Huaxue Zazhi. Volume 24. Issue 2. Pages 90-93. Journal. (2014).

Rivaroxaban - Synthetic Route 2

Rivaroxaban route02

Synthetic reference

Prasangi, Sridhar; Desireddy, Srinivas Reddy; Rao, Velivela Srinivsasa; Murthy, Y. L. N.; Palla, Mahesh. An improved synthesis of (S)​-​5-​chloro-​N-​{[2-​oxo-​3-​[4-​(3-​oxomorpholin-​4-​yl)​phenyl]​oxazolidin-​5-​yl]​methyl}​thiophene-​2-​carboxamide. Chemical Science Transactions. Volume 6. Issue 1. Pages 27-34. Journal; Online Computer File. (2017).

Rivaroxaban - Synthetic Route 3

Rivaroxaban route03

Synthetic reference

Gao, Nana; Sun, Hongbin. Synthesis and factor Xa inhibitory activity of rivaroxaban derivatives. Zhongguo Yaoke Daxue Xuebao. Volume 42. Issue 5. Pages 392-399. Journal. (2011).

Rivaroxaban - Synthetic Route 4

Rivaroxaban route04

Synthetic reference

Yuan, Jianyong; Liu, Kai; Li, Lun; Yuan, Yong; Liu, Xuelei; Li, Yanwu. A novel synthesis of the oxazolidinone antithrombotic agent rivaroxaban. Molecules. Volume 19. Issue 9. Pages 14999-15004, 6 pp. Journal; Online Computer File. (2014).

Rivaroxaban - Synthetic Route 5

Rivaroxaban route05

Synthetic reference

Drabina, Pavel; Feixova, Viola; Sedlak, Milos. New synthetic strategy for preparation of the anticoagulant drug Rivaroxaban via an asymmetric Henry reaction. Tetrahedron Letters. Volume 60. Issue 2. Pages 99-101. Journal; Online Computer File. (2019).

Rivaroxaban - Synthetic Route 6

Rivaroxaban route06

Synthetic reference

Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian. An approach to the anticoagulant agent rivaroxaban via an isocyanate-​oxirane cycloaddition promoted by MgI2.etherate. Journal of Chemical Research. Volume 35. Issue 7. Pages 400-401. Journal. (2011).

Rivaroxaban - Synthetic Route 7

Rivaroxaban route07

Synthetic reference

: Fu, Jian; Zhu, Xiao-hua; Li, Qiang; Chen, Guo-hua. Improvement of synthesis of rivaroxaban. Anhui Yiyao. Volume 17. Issue 6. Pages 917-918. Journal. (2013).

Rivaroxaban - Synthetic Route 8

Rivaroxaban route08

Synthetic reference

Yuan, Jing; Huang, Chang-jiang; Zhang, Jun-wei; Zhang, Shi-jun; Xu, Wei-ren. Synthesis of rivaroxaban. Zhang, Shi-jun; Xu, Wei-ren. Zhongguo Xinyao Zazhi. Volume 19. Issue 23. Pages 2184-2187. Journal. (2010).

Rivaroxaban - Synthetic Route 9

Rivaroxaban route09

Synthetic reference

Zhou, Zijin; Chen, Feng; Luo, Xinzu; Huang, Junhao. Preparation process of rivaroxaban. Assignee Suzhou Zhonglian Chemical Pharmaceutical Co., Ltd., Peop. Rep. China. CN 108690010. (2018).

Rivaroxaban - Synthetic Route 10

Rivaroxaban route010

Synthetic reference

Yan, Jie; Wang, Zhifeng. Method for synthesizing and refining rivaroxaban. Assignee Tianjin Hanrui Pharmaceutical Co., Ltd., Peop. Rep. China. CN 107382993. (2017).