Ulipristal

CAT#: H341363

CAS#: 159811-51-5

Description: Ulipristal acetate, also known as CDB-2914, is a selective progesterone receptor modulator (SPRM) approved for contraception, and for uterine fibroid. As a SPRM, ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to the glucocorticoid receptor, but is only a weak antiglucocorticoid relative to mifepristone, and has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.

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Synthetic Routes

Ulipristal - Synthetic Route 1

Ulipristal route01

Synthetic reference

Kim, Hyun K.; Rao, Pemmaraju Narasinha; Burdett, James E., Jr.; Acosta, Carmie Kirk. improved preparation of 17α-acetoxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and its intermediates. Assignee United States Dept. of Health and Human Services, USA. WO 9630390. (1996).

Ulipristal - Synthetic Route 2

Ulipristal route02

Synthetic reference

Wu, Yong; Guan, Mei; Hao, Wenmei; Hai, Li; Yu, Yongguo; Li, Xiaocen. Synthesis of Ulipristal acetate. Assignee Sichuan University, Peop. Rep. China. CN 103601785. (2014).

Ulipristal - Synthetic Route 3

Ulipristal route03

Synthetic reference

Dancsi, Lajosne; Visky, Gyoergy; Tuba, Zoltan; Csoergei, Janos; Molnar, Csaba; Magyari, Endrene. Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process. Assignee Richter Gedeon Nyrt, Hung. WO 2007144674. (2007).

Ulipristal - Synthetic Route 4

Ulipristal route04

Synthetic reference

Cheng, Xu; Li, Xiaocen; Duan, Yanjun; Yu, Yongguo; Hai, Li; Wu, Yong. A new and efficient method for the synthesis of Ulipristal acetate. Steroids. Volume 84. Pages 78-83. 2014.

Ulipristal - Synthetic Route 5

Ulipristal route05

Synthetic reference

Li, Hang; He, Dangjun. Method for synthesis of Ulipristal acetate, a progesterone receptor regulator. Assignee SFFT Developing Co., Ltd., Peop. Rep. China. CN 102372760. (2012).

Ulipristal - Synthetic Route 6

Ulipristal route06

Synthetic reference

Luo, Junzhi; Sun, Yongqiang; Luo, Xun; Yan, Yimin; Wang, Zhaojun; Qian, Mingxia; Tu, Yongrui. Method for preparation of Ulipristal acetate and its key intermediate. Assignee Changzhou Siyao Pharm Co., Ltd., Peop. Rep. China; UTOpharm (Shanghai) Co., Ltd. WO 2013063859. (2013).

Ulipristal - Synthetic Route 7

Ulipristal route07

Synthetic reference

Wu, Yong; Guan, Mei; Hao, Wenmei; Hai, Li; Yu, Yongguo; Li, Xiaocen. Synthesis of Ulipristal acetate. Assignee Sichuan University, Peop. Rep. China. CN 103601785. (2014).

Ulipristal - Synthetic Route 8

Ulipristal route08

Synthetic reference

Wang, Hai; Tian, Weixue; Shi, Xuesong. New steroid compound, its preparation method and application. Assignee Beijing Zizhu Pharmaceutical Co., Ltd., Peop. Rep. China; China Resources Zizhu Pharmaceutical Co., Ltd. CN 102477060. (2012).

Ulipristal - Synthetic Route 9

Ulipristal route09

Synthetic reference

Zhang, Tongli. Synthesis method of ulipristal acetate as progesterone agonist/antagonist. Assignee Guangzhou Tosun Pharmaceutical Ltd., Peop. Rep. China. CN 107629107. (2018).

Ulipristal - Synthetic Route 10

Ulipristal route010

Synthetic reference

Ray, Purna Chandra; Pathade, Ajinath Tukaram; Patil, Suryaprakash Pandurang; Chavan, Yuvraj Atmaram; Singh, Girij Pal. Novel process and intermediate for the preparation of ulipristal. Assignee Lupin Limited, India. IN 2012KO01188. (2016).