Tafluprost

CAT#: H314238

CAS#: 209860-87-7

Description: Tafluprost, also known as MK2452 and AFP-168, is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.

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Synthetic Routes

Tafluprost - Synthetic Route 1

Tafluprost route01

Synthetic reference

Syu, Jin-Fong; Wang, Yun-Ting; Liu, Kung-Cheng; Wu, Ping-Yu; Henschke, Julian P.; Wu, Hsyueh-Liang. Rh(I)​-​Catalyzed 1,​4-​Conjugate Addition of Alkenylboronic Acids to a Cyclopentenone Useful for the Synthesis of Prostaglandins. Journal of Organic Chemistry. Volume 81. Issue 22. Pages 10832-10844. Journal; Online Computer File. (2016).

Tafluprost - Synthetic Route 2

Tafluprost route02

Synthetic reference

Matsumura, Yasushi; Nakano, Takashi; Mori, Nobuaki; Morizawa, Yoshitomi. Synthesis and biological properties of novel fluoroprostaglandin derivatives: highly selective and potent agonists for prostaglandin receptors. Chimia. Volume 58. Issue 3. Pages 148-152. Journal. (2004).

Tafluprost - Synthetic Route 3

Tafluprost route03

Synthetic reference

Wei, Shih-Yi; Yeh, Yu-Chih; Hsu, Min-Kuan; Kao, Li-Ta. Preparation of isomer-free prostaglandins and their intermediates. Assignee Chirogate International Inc., Taiwan. US 20170015646. (2017).

Tafluprost - Synthetic Route 4

Tafluprost route04

Synthetic reference

Lee, Hyo Seon; Song, Gyeong Heon; Shin, Hyeon Ik. Method for the preparation of tafluprost. Assignee Yonsung Fine Chemical Co., Ltd., S. Korea. KR 2016116402. (2016).

Tafluprost - Synthetic Route 5

Tafluprost route05

Synthetic reference

Yang, Bo; Peng, Yue. A process for preparing tafluprost. Assignee Tianze Enyuan (Tianjin) Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 103804195. (2014).

Tafluprost - Synthetic Route 6

Tafluprost route06

Synthetic reference

Tsai, Chia-Chung; Chen, Chien-Yuh; Liang, Sen-Bau; Lo, Yu-Chi; Yao, Chi-Hsiang. Process for the purification of tafluprost and travoprost by removing fluorine containing impurity using preparative HPLC. Assignee Everlight USA, Inc., USA. US 20140051882. (2014).

Tafluprost - Synthetic Route 7

Tafluprost route07

Synthetic reference

Wen, Wen-Hsien. Process for preparation of tafluprost and intermediates thereof. Assignee ScinoPharm (Changshu) Pharmaceuticals, Ltd., Peop. Rep. China. WO 2014023256. (2014).

Tafluprost - Synthetic Route 8

Tafluprost route08

Synthetic reference

Jackson, Mark P. Preparation of pure prostaglandin analogs via prostaglandin analog amine salt intermediates. Assignee Dr. Reddy's Laboratories Limited, India. WO 2013118058. (2013).

Tafluprost - Synthetic Route 9

Tafluprost route09

Synthetic reference

Zhang, Jian; Wang, Runqing; Yu, Jianghui. Preparation method for high-purity Tafluprost and analogue. Assignee Suzhou Lanxite Biotechnology Co., Ltd., Peop. Rep. China. CN 107226790. (2017).