Olutasidenib

CAT#: H207008

CAS#: 1887014-12-1

Description: Olutasidenib, also known as FT-2102, is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. FT-2102 has excellent ADME/PK properties and reduces 2-hydroxyglutarate levels in an mIDH1 xenograft tumor model.

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Synthetic Routes

Olutasidenib - Synthetic Route 1

Olutasidenib route01

Synthetic reference

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

By: Caravella, Justin A. ; et al

Journal of Medicinal Chemistry (2020), 63(4), 1612-1623

Olutasidenib - Synthetic Route 2

Olutasidenib route02

Synthetic reference

Treating cancer patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation By: Kelly, Patrick F.; et al United States, US20190350922 A1 2019-11-21