Plecanatide

CAT#: H1036327

CAS#: 467426-54-6

Description: Plecanatide (brand name Trulance), is a drug approved by the FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP.

img

Synthetic Routes

Plecanatide - Synthetic Route 1

Plecanatide route01

Synthetic reference

Plecanatide - Synthetic Route 2

Plecanatide route02

Synthetic reference

Plecanatide - Synthetic Route 3

Plecanatide route03

Synthetic reference

Plecanatide - Synthetic Route 4

Plecanatide route04

Synthetic reference

Zhu, Yishen; Zhou, Yunlong; Wei, Ping; Ouyang, Pingkai. Process for preparation of plecanatide. Assignee Nanjing Tech University, Peop. Rep. China. CN 104628827 A (2015).

Plecanatide - Synthetic Route 5

Plecanatide route05

Synthetic reference

Zhu, Richeng; Mi, Pengcheng; Ma, Yaping; Yuan, Jiancheng. Process for preparation of plecanatide. Assignee Hybio Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103694320 A (2014).

Plecanatide - Synthetic Route 6

Plecanatide route06

Synthetic reference

Xu, Feng; Su, Jun; Gu, Haitao; Zhou, Jinyu; Liu, Biao; Sun, Meilu. Preparation of plecanatide by solid-phase peptide synthesis method. Assignee SINOPEP Jiangsu Inc., Peop. Rep. China. CN 108003222 A (2018).