Trifluridine

CAT#: H206038

CAS#: 70-00-8

Description: Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. It is a component of the experimental anti-cancer drug TAS-102.

img

Synthetic Routes

Trifluridine - Synthetic Route 1

Trifluridine route01

Synthetic reference

Trifluridine - Synthetic Route 2

Trifluridine route02

Synthetic reference

Trifluridine - Synthetic Route 3

Trifluridine route03

Synthetic reference

Trifluridine - Synthetic Route 4

Trifluridine route04

Synthetic reference

Trifluridine - Synthetic Route 5

Trifluridine route05

Synthetic reference

Trifluridine - Synthetic Route 6

Trifluridine route06

Synthetic reference

Trifluridine - Synthetic Route 7

Trifluridine route07

Synthetic reference

Ji, Yining; Brueckl, Tobias; Baxter, Ryan D.; Fujiwara, Yuta; Seiple, Ian B.; Su, Shun; Blackmond, Donna G.; Baran, Phil S. Innate C-H trifluoromethylation of heterocycles. Proceedings of the National Academy of Sciences of the United States of America. Volume 108. Issue 35. Pages 14411-14415. 2011.

Trifluridine - Synthetic Route 8

Trifluridine route08

Synthetic reference

Fang, Zhongxue; Ning, Yongquan; Mi, Pengbing; Liao, Peiqiu; Bi, Xihe. Catalytic C-H α-Trifluoromethylation of α,β-Unsaturated Carbonyl Compounds. Organic Letters. Volume 16. Issue 5. Pages 1522-1525. 2014

Trifluridine - Synthetic Route 9

Trifluridine route09

Synthetic reference

Kumar, Vineet; Malhotra, Sanjay V. Synthesis of nucleoside-based antiviral drugs in ionic liquids. Bioorganic & Medicinal Chemistry Letters. Volume 18. Issue 20. Pages 5640-5642. 2008.

Trifluridine - Synthetic Route 10

Trifluridine route010

Synthetic reference

Yang, Binghui; Qiu, Jingang; Ling, Guochang. Method for preparation of 5-trifluoromethyl-2'-deoxyuridine. Assignee Hangzhou Fubang Biological Pharmacy Co., Ltd., Peop. Rep. China. CN 1640882 A (2005).