Valsartan

CAT#: H318970

CAS#: 137862-53-4

Description: Valsartan is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.

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Synthetic Routes

Valsartan - Synthetic Route 1

Valsartan route01

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Valsartan - Synthetic Route 2

Valsartan route02

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Valsartan - Synthetic Route 3

Valsartan route03

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Valsartan - Synthetic Route 4

Valsartan route04

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Valsartan - Synthetic Route 5

Valsartan route05

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Valsartan - Synthetic Route 6

Valsartan route06

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Valsartan - Synthetic Route 7

Valsartan route07

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Chen, Liye; Ren, Peng; Carrow, Brad P. Tri(1-adamantyl)phosphine: Expanding the Boundary of Electron-Releasing Character Available to Organophosphorus Compounds. Journal of the American Chemical Society. Volume 138. Issue 20. Pages 6392-6395. 2016.

Valsartan - Synthetic Route 8

Valsartan route08

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Sedelmeier, Gottfried. A preparation of tetrazole derivatives via heterocyclization of nitriles with azides. Assignee Novartis A.-G., Switz.; Novartis Pharma G.m.b.H. WO 2005014602 A1. (2005).

Valsartan - Synthetic Route 9

Valsartan route09

Synthetic reference

Zhang, Chen Xi; Zheng, Guo Jun; Bi, Fu Qiang; Li, Yu Lin. A simple and efficient synthesis of the valsartan. Chinese Chemical Letters. Volume 19. Issue 7. Pages 759-761. 2008.