WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525085
CAS#: 105346-34-7
Description: FR 62765 is a derivative of WF-3681,a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy.
Hodoodo Cat#: H525085
Name: FR 62765
CAS#: 105346-34-7
Chemical Formula: C16H18O5
Exact Mass: 290.12
Molecular Weight: 290.310
Elemental Analysis: C, 66.19; H, 6.25; O, 27.56
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Synonym: FR 62765; FR-62765; FR62765.
IUPAC/Chemical Name: 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester
InChi Key: ODHJHYPKZNTPCS-GFCCVEGCSA-N
InChi Code: InChI=1S/C16H18O5/c1-3-20-13(17)10-9-12-14(11-7-5-4-6-8-11)15(19-2)16(18)21-12/h4-8,12H,3,9-10H2,1-2H3/t12-/m1/s1
SMILES Code: O1[C@@H](C(=C(C1=O)OC)c1ccccc1)CCC(=O)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 290.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Nishikawa M, Yoshida K, Okamoto M, Itoh Y, Kohsaka M. Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo). 1991 Apr;44(4):441-4. PubMed PMID: 1903376.