WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525115
CAS#: 189699-82-9
Description: FR-188582 is a highly selective inhibitor of COX-2. It has anti-inflammatory and ulcerogenic effects. FR188582 inhibited COX-2 with an IC50 value of 0.017 microM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 was over 6000 times more selective for COX-2 than COX-1. FR-188582 has potent anti-inflammatory effect mediated by inhibition of PGE2 in inflamed tissues.
Hodoodo Cat#: H525115
Name: FR-188582
CAS#: 189699-82-9
Chemical Formula: C16H13ClN2O2S
Exact Mass: 332.04
Molecular Weight: 332.800
Elemental Analysis: C, 57.74; H, 3.94; Cl, 10.65; N, 8.42; O, 9.61; S, 9.63
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Synonym: FR-188582; FR 188582; FR188582.
IUPAC/Chemical Name: 1H-Pyrazole, 3-chloro-5-(4-(methylsulfonyl)phenyl)-1-phenyl-
InChi Key: YKHNOHGHDAQJFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13ClN2O2S/c1-22(20,21)14-9-7-12(8-10-14)15-11-16(17)18-19(15)13-5-3-2-4-6-13/h2-11H,1H3
SMILES Code: CS(=O)(=O)c1ccc(cc1)c2cc(nn2c3ccccc3)Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 332.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Abe T, Hayasaka Y, Zhang XY, Hayasaka S. Effects of intravenous administration of FR122047 (a selective cyclooxygenase 1 inhibitor) and FR188582 (a selective cyclooxygenase 2 inhibitor) on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits. Ophthalmic Res. 2004 Nov-Dec;36(6):321-6. PubMed PMID: 15627832.
2: Ochi T, Yamane-Sugiyama A, Ohkubo Y, Sakane K, Tanaka H. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82. PubMed PMID: 11286400.