WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525141
CAS#: 486-28-2
Description: Fraxinol is a coumarin originally isolated from Ash tree bark. It inhibits growth of GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells.
Hodoodo Cat#: H525141
Name: Fraxinol
CAS#: 486-28-2
Chemical Formula: C11H10O5
Exact Mass: 222.05
Molecular Weight: 222.190
Elemental Analysis: C, 59.46; H, 4.54; O, 36.00
Synonym: Fraxinol
IUPAC/Chemical Name: 2H-1-Benzopyran-2-one, 6-hydroxy-5,7-dimethoxy-
InChi Key: PBPNOAHYDPHKFH-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)11(15-2)10(8)13/h3-5,13H,1-2H3
SMILES Code: COc1cc2c(ccc(=O)o2)c(c1O)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 222.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Spath, E., and Jerzmanowska-Sienkiewiczowa, Z. Natural coumarins. XXV. Fraxinol, a new constituent of the bark of the ash. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 70B, 698-702 (1937).
2. Kolodziej, H., Kayser, O., Woerdenbag, H.J., et al. Structure-cytotoxicity relationships of a series of natural and semi-synthetic simple coumarins as assessed in two human tumour cell lines. Z. Naturforsch. C 52(3-4), 240-244 (1997).
3. Khadzhai, Y.I. Effect of coumarin, flavonoid, and khellin derivatives on the soporific effect of barbiturates. Farmakologiya i Toksikologiya (Kiev) 7, 46-48 (1972).