WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526762
CAS#: 264218-23-7
Description: SB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes.
Hodoodo Cat#: H526762
Name: SB-415286
CAS#: 264218-23-7
Chemical Formula: C16H10ClN3O5
Exact Mass: 359.03
Molecular Weight: 359.722
Elemental Analysis: C, 53.42; H, 2.80; Cl, 9.85; N, 11.68; O, 22.24
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: SB-415286; SB 415286; SB415286.
IUPAC/Chemical Name: 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
InChi Key:
InChi Code:
SMILES Code: O=C(C(NC1=CC=C(O)C(Cl)=C1)=C2C3=CC=CC=C3[N+]([O-])=O)NC2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 359.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Pizarro JG, Folch J, Esparza JL, Jordan J, Pallàs M, Camins A. A molecular
study of pathways involved in the inhibition of cell proliferation in
neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. J Cell Mol
Med. 2009 Sep;13(9B):3906-17. doi: 10.1111/j.1582-4934.2008.00389.x. Epub 2008
Jun 20. PubMed PMID: 18624766; PubMed Central PMCID: PMC4516538.
2: Yeste-Velasco M, Folch J, Jiménez A, Rimbau V, Pallàs M, Camins A. GSK-3 beta
inhibition and prevention of mitochondrial apoptosis inducing factor release are
not involved in the antioxidant properties of SB-415286. Eur J Pharmacol. 2008
Jul 7;588(2-3):239-43. doi: 10.1016/j.ejphar.2008.04.019. Epub 2008 Apr 11.
PubMed PMID: 18502415.
3: Pizarro JG, Yeste-Velasco M, Rimbau V, Casadesús G, Smith MA, Pallàs M, Folch
J, Camins A. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced
cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci. 2008
May-Jun;26(3-4):269-76. doi: 10.1016/j.ijdevneu.2008.02.002. Epub 2008 Feb 8.
PubMed PMID: 18342477.
4: MacAulay K, Hajduch E, Blair AS, Coghlan MP, Smith SA, Hundal HS. Use of
lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the
regulation of glucose transport and glycogen synthase. Eur J Biochem. 2003
Sep;270(18):3829-38. PubMed PMID: 12950267.
