WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208510
CAS#: 5469-26-1
Description: 1-Bromopinacolone is an active site-directed covalent inhibitor for acetylcholinesterase
Hodoodo Cat#: H208510
Name: 1-Bromopinacolone
CAS#: 5469-26-1
Chemical Formula: C6H11BrO
Exact Mass: 178.00
Molecular Weight: 179.060
Elemental Analysis: C, 40.25; H, 6.19; Br, 44.62; O, 8.94
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Synonym: Bromopinacolin, Bromomethyl tert-butyl ketone, omega- Brompinakolin, Pivaloylmethyl bromide, tert-Butyl bromomethyl ketone
IUPAC/Chemical Name: 1-Bromo-3,3-dimethylbutan-2-one
InChi Key: SAIRZMWXVJEBMO-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H11BrO/c1-6(2,3)5(8)4-7/h4H2,1-3H3
SMILES Code: CC(C)(C)C(=O)CBr
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 179.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Cohen SG, Lieberman DL, Hasan FB, Cohen JB. 1-Bromopinacolone, an active site-directed covalent inhibitor for acetylcholinesterase. J Biol Chem. 1982 Dec 10;257(23):14087-92. PMID: 7142196.
2: Cohen SG, Salih E, Solomon M, Howard S, Chishti SB, Cohen JB. Reactions of 1-bromo-2-[14C]pinacolone with acetylcholinesterase from Torpedo nobiliana. Effects of 5-trimethylammonio-2-pentanone and diisopropyl fluorophosphate. Biochim Biophys Acta. 1989 Aug 31;997(3):167-75. doi: 10.1016/0167-4838(89)90182-9. PMID: 2765553.
3: Salih E, Howard S, Chishti SB, Cohen SG, Liu WS, Cohen JB. Labeling of cysteine 231 in acetylcholinesterase from Torpedo nobiliana by the active-site directed reagent, 1-bromo-2-[14C] pinacolone. Effects of 2,2'-dipyridyl disulfide and other sulfhydryl reagents. J Biol Chem. 1993 Jan 5;268(1):245-51. PMID: 8416933.
4: Salih E, Chishti SB, Vicedomine P, Cohen SG, Chiara DC, Cohen JB. Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate. Biochim Biophys Acta. 1994 Oct 19;1208(2):324-31. doi: 10.1016/0167-4838(94)90120-1. Erratum in: Biochim Biophys Acta 1995 Jan 5;1246(1):107. PMID: 7947965.
