CID661578

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Hodoodo CAT#: H208466

CAS#: 799796-04-6

Description: CID661578 is an inducer of β-cell regeneration, but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that CID661578 targets MAP kinase-interacting serine/threonine kinase 2 (MNK2), an interaction we genetically validated in vivo. CID661578 increased β-cell neogenesis from ductal cells in zebrafish, neonatal pig islet aggregates and human pancreatic ductal organoids.

Chemical Structure

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CID661578
CAS# 799796-04-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H208466
Name: CID661578
CAS#: 799796-04-6
Chemical Formula: C19H17FN2O4
Exact Mass: 356.12
Molecular Weight: 356.350
Elemental Analysis: C, 64.04; H, 4.81; F, 5.33; N, 7.86; O, 17.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CID-661578

IUPAC/Chemical Name: 7-Fluoro-N-(furan-2-ylmethyl)-2-hydroxy-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxamid

InChi Key: DJKOBSQAIJTFKF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17FN2O4/c1-10-4-5-11-7-12(20)8-14-16(11)22(10)19(25)15(17(14)23)18(24)21-9-13-3-2-6-26-13/h2-3,6-8,10,25H,4-5,9H2,1H3,(H,21,24)

SMILES Code: O=C(C(C1=O)=C(O)N2C(C)CCC3=C2C1=CC(F)=C3)NCC4=CC=CO4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 356.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, Liu X, Chu L, Locasale JW, Korbutt GS, Rovira M, Larsson O, Andersson O. MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nat Chem Biol. 2022 Sep;18(9):942-953. doi: 10.1038/s41589-022-01047-x. Epub 2022 Jun 13. PMID: 35697798; PMCID: PMC7613404.