WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121124
CAS#: Unknown
Description: MRS4719 is a P2X4 Receptor Antagonist. MRS4719 has translational potential for treating ischemic stroke, including in aging populations.
Hodoodo Cat#: H121124
Name: MRS4719
CAS#: Unknown
Chemical Formula: C26H28N6O3S
Exact Mass: 504.19
Molecular Weight: 504.609
Elemental Analysis: C, 61.89; H, 5.59; N, 16.65; O, 9.51; S, 6.35
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Synonym: MRS4719; MRS-4719; MRS 4719
IUPAC/Chemical Name: 5-(2-(5-thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-4-yl)-1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione compound with triethylamine (1:1)
InChi Key: MTKQIUDYZPMMBH-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H13N5O3S.C6H15N/c26-16-10-17(27)25(12-7-8-21-14(9-12)19-23-20(29)28-24-19)15-6-5-11-3-1-2-4-13(11)18(15)22-16;1-4-7(5-2)6-3/h1-9H,10H2,(H,22,26)(H,23,24,29);4-6H2,1-3H3
SMILES Code: S=C1NC(C2=NC=CC(N(C3=CC=C(C=CC=C4)C4=C3N5)C(CC5=O)=O)=C2)=NO1.CCN(CC)CC
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 504.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Toti KS, Verma R, McGonnigle MJ, Gamiotea Turro D, Wen Z, Lewicki SA, Liang BT, Jacobson KA. Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-diones as P2X4 Receptor Antagonists. J Med Chem. 2022 Sep 23. doi: 10.1021/acs.jmedchem.2c01197. Epub ahead of print. PMID: 36150180.