WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121047
CAS#: 2488395-07-7
Description: RNO-6 is a Rho-associated protein kinase (ROCK) inhibitor. RNO-6 maintained potent ROCK inhibitory and NO releasing abilities, reversibly depolymerized F-actin, and suppressed mitochondrial respiration in human trabecular meshwork (HTM) cells. RNO-6 could be a promising agent for glaucoma or ocular hypertension, warranting further investigation.
Hodoodo Cat#: H121047
Name: RNO-6
CAS#: 2488395-07-7
Chemical Formula: C20H25FN4O7S.ClH
Exact Mass: 520.12
Molecular Weight: 520.960
Elemental Analysis: C, 46.11; H, 5.03; Cl, 6.80; F, 3.65; N, 10.75; O, 21.50; S, 6.15
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Synonym: RNO-6; RNO6; RNO 6
IUPAC/Chemical Name: 4-(nitrooxy)butyl (S)-4-((4-fluoroisoquinolin-5-yl)sulfonyl)-3-methyl-1,4-diazepane-1-carboxylate hydrochloride
InChi Key: PWJPEYUHWFWQON-RSAXXLAASA-N
InChi Code: InChI=1S/C20H25FN4O7S.ClH/c1-15-14-23(20(26)31-10-2-3-11-32-25(27)28)8-5-9-24(15)33(29,30)18-7-4-6-16-12-22-13-17(21)19(16)18;/h4,6-7,12-13,15H,2-3,5,8-11,14H2,1H3;1H/t15-;/m0./s1
SMILES Code: FC1=C2C(C=CC=C2S(N3[C@@H](C)CN(C(OCCCCO[N+]([O-])=O)=O)CCC3)(=O)=O)=CN=C1.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 520.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Yang Z, Wu J, Wu K, Luo J, Li C, Zhang J, Zhao M, Mei T, Liu X, Shang B, Zhang Y, Zhao L, Huang Z. Identification of Nitric Oxide-Donating Ripasudil Derivatives with Intraocular Pressure Lowering and Retinal Ganglion Cell Protection Activities. J Med Chem. 2022 Sep 8;65(17):11745-11758. doi: 10.1021/acs.jmedchem.2c00600. Epub 2022 Aug 25. PMID: 36007247.