WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121027
CAS#: Unknown
Description: SJPYT-195: A Designed Nuclear Receptor Degrader that functions as a Molecular Glue Degrader of GSPT1. SJPYT-195 was a molecular glue degrader of the translation termination factor GSPT1 and that GSPT1 degradation resulted in subsequent reduction of PXR protein.
Hodoodo Cat#: H121027
Name: SJPYT-195
CAS#: Unknown
Chemical Formula: C35H34N6O8
Exact Mass: 666.24
Molecular Weight: 666.690
Elemental Analysis: C, 63.06; H, 5.14; N, 12.61; O, 19.20
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Synonym: SJPYT-195; SJPYT195; SJPYT 195
IUPAC/Chemical Name: N-(3-(tert-butyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
InChi Key: YYDMLWLLMFAABT-UHFFFAOYSA-N
InChi Code: InChI=1S/C35H34N6O8/c1-18-30(38-39-41(18)25-17-21(47-5)10-12-26(25)48-6)32(44)36-20-14-19(35(2,3)4)15-22(16-20)49-27-9-7-8-23-29(27)34(46)40(33(23)45)24-11-13-28(42)37-31(24)43/h7-10,12,14-17,24H,11,13H2,1-6H3,(H,36,44)(H,37,42,43)
SMILES Code: COC1=CC(N2N=NC(C(NC3=CC(OC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=CC(C(C)(C)C)=C3)=O)=C2C)=C(OC)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 666.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Huber AD, Li Y, Lin W, Galbraith AN, Mishra A, Porter SN, Wu J, Florke Gee RR, Zhuang W, Pruett-Miller SM, Peng J, Chen T. SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320. doi: 10.1021/acsmedchemlett.2c00223. PMID: 35978691; PMCID: PMC9377019.