WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121102
CAS#: 1591823-76-5
Description: Ulonivirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor in clinical development with potential for once-weekly oral administration for the treatment of HIV-1 infection.
Hodoodo Cat#: H121102
Name: Ulonivirine
CAS#: 1591823-76-5
Chemical Formula: C18H8ClF6N5O3
Exact Mass: 491.02
Molecular Weight: 491.730
Elemental Analysis: C, 43.97; H, 1.64; Cl, 7.21; F, 23.18; N, 14.24; O, 9.76
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Synonym: Ulonivirine; MK-8507; MK8507; MK 8507
IUPAC/Chemical Name: 3-chloro-5-{[6-oxo-1-{[6-oxo-5-(trifluoromethyl)-1,6- dihydropyridazin-3-yl]methyl}-4-(trifluoromethyl)-1,6- dihydropyrimidin-5-yl]oxy}benzonitrile
InChi Key: YSFHLBYWQCLYIY-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H8ClF6N5O3/c19-9-1-8(5-26)2-11(3-9)33-13-14(18(23,24)25)27-7-30(16(13)32)6-10-4-12(17(20,21)22)15(31)29-28-10/h1-4,7H,6H2,(H,29,31)
SMILES Code: O=C1C(C(F)(F)F)=CC(CN(C=NC(C(F)(F)F)=C2OC3=CC(C#N)=CC(Cl)=C3)C2=O)=NN1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 491.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Ankrom W, Jackson Rudd D, Schaeffer A, Panebianco D, Friedman EJ, Tomek C, Stoch SA, Iwamoto M. Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0093521. doi: 10.1128/AAC.00935-21. Epub 2021 Sep 13. PMID: 34516246; PMCID: PMC8597757.