WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121142
CAS#: 2725749-22-2
Description: GRL-0820 is a SARS-CoV-2 Protease inhibitor (IC50 = 73 nM). GRL-0820 blocked SARS-CoV-2 infection but viral breakthrough occurred.
Hodoodo Cat#: H121142
Name: GRL-0820
CAS#: 2725749-22-2
Chemical Formula: C17H13ClN2O2
Exact Mass: 312.07
Molecular Weight: 312.750
Elemental Analysis: C, 65.29; H, 4.19; Cl, 11.33; N, 8.96; O, 10.23
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Synonym: GRL-0820; GRL0820; GRL 0820
IUPAC/Chemical Name: 5-chloropyridin-3-yl 1-allyl-1H-indole-4-carboxylate
InChi Key: XBVPAGLILYEOGS-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13ClN2O2/c1-2-7-20-8-6-14-15(4-3-5-16(14)20)17(21)22-13-9-12(18)10-19-11-13/h2-6,8-11H,1,7H2
SMILES Code: ClC1=CN=CC(OC(C2=CC=CC3=C2C=CN3CC=C)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 312.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Hattori SI, Higshi-Kuwata N, Raghavaiah J, Das D, Bulut H, Davis DA, Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R, Maeda K, Ghosh AK, Mitsuya H. GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection. mBio. 2020 Aug 20;11(4):e01833-20. doi: 10.1128/mBio.01833-20. PMID: 32820005; PMCID: PMC7441487.