WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121143
CAS#: 2835511-03-8
Description: GRL-1720 is a SARS-CoV-2 Protease inhibitor (IC50 = 320 nM). GRL-1720 contains an indoline which targets the SARS-CoV-2 main protease (Mpro)
Hodoodo Cat#: H121143
Name: GRL-1720
CAS#: 2835511-03-8
Chemical Formula: C14H11ClN2O2
Exact Mass: 274.05
Molecular Weight: 274.700
Elemental Analysis: C, 61.21; H, 4.04; Cl, 12.90; N, 10.20; O, 11.65
Synonym: GRL-1720; GRL1720; GRL 1720
IUPAC/Chemical Name: 5-chloropyridin-3-yl indoline-4-carboxylate
InChi Key: JROSKNTUYSPHGX-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11ClN2O2/c15-9-6-10(8-16-7-9)19-14(18)12-2-1-3-13-11(12)4-5-17-13/h1-3,6-8,17H,4-5H2
SMILES Code: ClC1=CN=CC(OC(C2=CC=CC3=C2CCN3)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 274.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2021 Jan 28;12(1):668. doi: 10.1038/s41467-021-20900-6. PMID: 33510133; PMCID: PMC7843602.