MAC-5576

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H121144

CAS#: 219929-01-8

Description: MAC-5576 a SARS-CoV-2 Protease inhibitor (IC50 = 81 nM).

Chemical Structure

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MAC-5576
CAS# 219929-01-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H121144
Name: MAC-5576
CAS#: 219929-01-8
Chemical Formula: C10H6ClNO2S
Exact Mass: 238.98
Molecular Weight: 239.673
Elemental Analysis: C, 50.11; H, 2.52; Cl, 14.79; N, 5.84; O, 13.35; S, 13.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MAC-5576; MAC5576; MAC 5576

IUPAC/Chemical Name: 5-chloropyridin-3-yl thiophene-2-carboxylate

InChi Key: PAVJYVVZIJTAHT-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H6ClNO2S/c11-7-4-8(6-12-5-7)14-10(13)9-2-1-3-15-9/h1-6H

SMILES Code: ClC1=CN=CC(OC(C2=CC=CS2)=O)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 239.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Iketani S, Forouhar F, Liu H, Hong SJ, Lin FY, Nair MS, Zask A, Huang Y, Xing L, Stockwell BR, Chavez A, Ho DD. Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nat Commun. 2021 Apr 1;12(1):2016. doi: 10.1038/s41467-021-22362-2. Erratum in: Nat Commun. 2021 May 5;12(1):2708. PMID: 33795671; PMCID: PMC8016852.