Phenyl-alpha-L-iduronide

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H208534

CAS#: 39031-71-5

Description: Phenyl-alpha-L-iduronide is an alpha-L-iduronidase substrate

Chemical Structure

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Phenyl-alpha-L-iduronide
CAS# 39031-71-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H208534
Name: Phenyl-alpha-L-iduronide
CAS#: 39031-71-5
Chemical Formula: C12H14O7
Exact Mass: 270.07
Molecular Weight: 270.340
Elemental Analysis: C, 53.34; H, 5.22; O, 41.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Phenyl-alpha-L-iduronide, PLIDN

IUPAC/Chemical Name: alpha-L-Idopyranosiduronic acid, phenyl

InChi Key: WVHAUDNUGBNUDZ-DSPMHBFJSA-N

InChi Code: InChI=1S/C12H14O7/c13-7-8(14)10(11(16)17)19-12(9(7)15)18-6-4-2-1-3-5-6/h1-5,7-10,12-15H,(H,16,17)/t7-,8-,9+,10+,12+/m0/s1

SMILES Code: O[C@H]([C@H]([C@@H]([C@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=CC=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Butterworth J, Broadhead DM. Comparison of the substrate 4-methylumbelliferyl-alpha-l-iduronide with phenyl-alpha-L-iduronide for the diagnosis of Hurler's disease in cultured cells. J Inherit Metab Dis. 1980;2(3):71-4. doi: 10.1007/BF01801722. PMID: 6796763.


2: Hopwood JJ, Muller V, Smithson A, Baggett N. A fluorometric assay using 4-methylumbelliferyl alpha-L-iduronide for the estimation of alpha-L-iduronidase activity and the detection of Hurler and Scheie syndromes. Clin Chim Acta. 1979 Mar 1;92(2):257-65. doi: 10.1016/0009-8981(79)90121-9. PMID: 114339.


3: Den Tandt WR, Scharpe S. Characteristics of leukocyte and plasma methylumbelliferyl-alpha-L-iduronide iduronidase. Biochem Med Metab Biol. 1989 Feb;41(1):18-24. doi: 10.1016/0885-4505(89)90003-0. PMID: 2713148.


4: Hopwood JJ, Muller V. Diagnostic enzymology of alpha-L-iduronidase with special reference to a sulphated disaccharide derived from heparin. Clin Sci (Lond). 1982 Feb;62(2):193-201. doi: 10.1042/cs0620193. PMID: 6895615.


5: Kosaka H, Isemura M, Ono T, Nishimura Y, Kato K. Studies on the alpha-L- iduronidase activity of beta-glucuronidase preparations from bovine liver, rat liver, and rat preputial gland. J Biochem. 1980 Jul;88(1):69-75. PMID: 7410341.


6: Schuchman EH, Guzman NA, Takada G, Desnick RJ. Human alpha-L-iduronidase. II. Comparative biochemical and immunologic properties of the purified low and high uptake forms. Enzyme. 1984;31(3):166-75. PMID: 6734578.


7: Kleijer WJ, Thompson EJ, Niermeijer MF. Prenatal diagnosis of the Hurler syndrome: report on 40 pregnancies at risk. Prenat Diagn. 1983 Jul;3(3):179-86. doi: 10.1002/pd.1970030302. PMID: 6413967.


8: Kleijer WJ, Hensing-Wolffers GM, Thompson EJ, Niermeijer MF. The Hurler syndrome: detection of patients and heterozygotes using a microassay for alpha- L-iduronidase in fibroblasts. Clin Chim Acta. 1981 Oct 8;116(1):47-54. doi: 10.1016/0009-8981(81)90167-4. PMID: 6797759.