PD 119819

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Hodoodo CAT#: H525828

CAS#: 105277-43-8

Description: PD 119819 is a heterocyclic piperazine and has been identified as an extremely selective DA autoreceptor agonist in tests that include [3H]haloperidol binding, inhibition of spontaneous locomotor activity, inhibition of brain DA synthesis, inhibition of brain DA neuronal firing, stereotypy assessment, and reversal of 6-hydroxydopamine (6-OHDA) induced akinesia in rats.

Chemical Structure

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PD 119819
CAS# 105277-43-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H525828
Name: PD 119819
CAS#: 105277-43-8
Chemical Formula: C21H23N3O3
Exact Mass: 365.17
Molecular Weight: 365.426
Elemental Analysis: C, 69.02; H, 6.34; N, 11.50; O, 13.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PD119819' PD-119819; PD 119819

IUPAC/Chemical Name: 7-(3-(4-(pyridin-2-yl)piperazin-1-yl)propoxy)-4H-chromen-4-one

InChi Key: NVGYZBZAFVGARK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2

SMILES Code: O=C1C=COC2=CC(OCCCN3CCN(C4=NC=CC=C4)CC3)=CC=C12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 365.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jaen JC, Wise LD, Heffner TG, Pugsley TA, Meltzer LT. Dopamine autoreceptor
agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. J
Med Chem. 1991 Jan;34(1):248-56. PubMed PMID: 1671416.