AW-464

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H208547

CAS#: 485842-97-5

Description: AW-464 is a novel thioredoxin inhibitor which was found to target the thioredoxin system in a cell-free assay. In HL-60 leukaemia cells, it was also found to induce Bak activation, cytochrome c release from mitochondria, decreasing Delta Psi m, chromatin condensation, phosphatidyl serine exposure and Tdt-sensitive DNA nicks.

Chemical Structure

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AW-464
CAS# 485842-97-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H208547
Name: AW-464
CAS#: 485842-97-5
Chemical Formula: C13H9NO2S
Exact Mass: 243.04
Molecular Weight: 243.280
Elemental Analysis: C, 64.18; H, 3.73; N, 5.76; O, 13.15; S, 13.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AW-464, 4-benzothiazol-HCHO, AW-464, PMX-464, UNII-YJX11V636Q

IUPAC/Chemical Name: 2,5-Cyclohexadien-1-one, 4-(2-benzothiazolyl)-4-hydroxy-

InChi Key: SDYBYKXWYDVVKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9NO2S/c15-9-5-7-13(16,8-6-9)12-14-10-3-1-2-4-11(10)17-12/h1-8,16H

SMILES Code: O=C1C=CC(O)(C2=NC3=CC=CC=C3S2)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 243.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Pallis M, Bradshaw TD, Westwell AD, Grundy M, Stevens MF, Russell N. Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochem Pharmacol. 2003 Nov 1;66(9):1695-705. doi: 10.1016/s0006-2952(03)00471-4. PMID: 14563480.