WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121165
CAS#: 2828476-76-0
Description: YZN76760 is a ProTAC building block. YZN76760 contains a von Hippel-Lindau (VHL)-recruting ligand, a rigid linker, and a pendant phosphoramidite for reactivity with target DNA-binding proteins such as transcription factors. This product has no formal name at the moment. For the convenience of communication, a temporal code was therefore proposed according to Hodoodo Chemical Nomenclature (see web page: https://www.hodoodo.com/page/naming).
Hodoodo Cat#: H121165
Name: YZN76760
CAS#: 2828476-76-0
Chemical Formula: C39H59N6O7PS
Exact Mass: 786.39
Molecular Weight: 786.970
Elemental Analysis: C, 59.52; H, 7.56; N, 10.68; O, 14.23; P, 3.94; S, 4.07
Synonym: (S,R,S)-AHPC-C5-phosphoramidite
IUPAC/Chemical Name: (3R,5S)-1-((2S)-2-(6-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl acetate
InChi Key: YMQQWUSOVSQPIT-ZGBSLLNRSA-N
InChi Code: InChI=1S/C39H59N6O7PS/c1-26(2)45(27(3)4)53(51-21-13-19-40)50-20-12-10-11-14-34(47)43-36(39(7,8)9)38(49)44-24-32(52-29(6)46)22-33(44)37(48)41-23-30-15-17-31(18-16-30)35-28(5)42-25-54-35/h15-18,25-27,32-33,36H,10-14,20-24H2,1-9H3,(H,41,48)(H,43,47)/t32-,33+,36-,53?/m1/s1
SMILES Code: CC(O[C@H]1CN(C([C@@H](NC(CCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O)C(C)(C)C)=O)[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 786.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
