WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121205
CAS#: Unknown
Description: UMN00761, also known as (S,R,S)-AHPC-PEG6-Alkyne, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used more quickly to generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to Hodoodo Chemical Nomenclature (see web page: https://www.hodoodo.com/page/naming).
Hodoodo Cat#: H121205
Name: UMN00761
CAS#: Unknown
Chemical Formula: C38H56N4O10S
Exact Mass: 760.37
Molecular Weight: 760.940
Elemental Analysis: C, 59.98; H, 7.42; N, 7.36; O, 21.03; S, 4.21
Synonym: (S,R,S)-AHPC-PEG6-Alkyne
IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16,19,22-hexaoxa-3-azapentacos-24-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key: ULIOMDKSUGRTNN-MEEYNGGZSA-N
InChi Code: InChI=1S/C38H56N4O10S/c1-6-12-47-14-16-49-18-20-51-22-23-52-21-19-50-17-15-48-13-11-33(44)41-35(38(3,4)5)37(46)42-26-31(43)24-32(42)36(45)39-25-29-7-9-30(10-8-29)34-28(2)40-27-53-34/h1,7-10,27,31-32,35,43H,11-26H2,2-5H3,(H,39,45)(H,41,44)/t31-,32+,35-/m1/s1
SMILES Code: O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 760.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
