WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122107
CAS#: 2432-99-7
Description: Aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Aminoundecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
Hodoodo Cat#: H122107
Name: Aminoundecanoic acid
CAS#: 2432-99-7
Chemical Formula: C11H23NO2
Exact Mass: 201.17
Molecular Weight: 201.310
Elemental Analysis: C, 65.63; H, 11.52; N, 6.96; O, 15.89
Synonym: 11-aminoundecanoic acid
IUPAC/Chemical Name: 11-aminoundecanoic acid
InChi Key: GUOSQNAUYHMCRU-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H23NO2/c12-10-8-6-4-2-1-3-5-7-9-11(13)14/h1-10,12H2,(H,13,14)
SMILES Code: OC(CCCCCCCCCCN)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 201.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: D'Aléo A, Pozzo JL, Fages F, Schmutz M, Mieden-Gundert G, Vögtle F, Caplar V,
Zinic M. 11-Aminoundecanoic acid: a versatile unit for the generation of low
molecular weight gelators for water and organic solvents. Chem Commun (Camb).
2004 Jan 21;(2):190-1. doi: 10.1039/b307846a. Epub 2003 Nov 18. PMID: 14737543.
2: Gatz-Schrupp J, Deckard P, Hufford B, Ly S, Tupa P, Masuda H. Isolation and
genomic analysis of 11-aminoundecanoic acid-degrading bacterium
Pseudomonas sp. JG-B from nylon 11 enrichment culture. J Genomics. 2020
Jan 25;8:16-20. doi: 10.7150/jgen.42095. PMID: 32064005; PMCID: PMC7019077.
3: Qian Z, Li S, He Y, Zhang H, Liu X. Hydrolytic degradation study of
biodegradable polyesteramide copolymers based on epsilon-caprolactone and
11-aminoundecanoic acid. Biomaterials. 2004 May;25(11):1975-81. doi:
10.1016/s0142-9612(03)00604-5. PMID: 14741611.
4: Dunnick JK, Huff JE, Haseman JK, Boorman GA. Lesions of the urinary tract
produced in Fischer 344 rats and B6C3F1 mice after chronic administration of
11-aminoundecanoic acid. Fundam Appl Toxicol. 1983 Nov-Dec;3(6):614-8. doi:
10.1016/s0272-0590(83)80111-0. PMID: 6662302.
5: Shen Z, Liu K, Zhou Z, Li Q. A pH controlled temperature response
reprogramming hydrogel for monitoring human electrophysiological signals. J
Mater Chem B. 2021 Jan 28;9(4):992-1001. doi: 10.1039/d0tb01769h. Epub 2021 Jan
4. PMID: 33395456.
6: Peter H, Föst U, Reinert T, Hallier E, Bolt HM. DNA binding assay with
11-aminoundecanoic acid-[11-14C] in F-344 rats. Arch Toxicol. 1987;61(1):86-7.
doi: 10.1007/BF00324555. PMID: 3439881.
