WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122159
CAS#: 1448189-80-7
Description: VHL Ligand 1 HCl salt is a synthetic E3 ligase ligand that is useful for PROTAC drug research & discovery. VHL Ligand 1 works by binding the Hippel-Lindau (VHL) E3 ligase portion of VHL-based PROTACs.
Hodoodo Cat#: H122159
Name: VHL Ligand 1 HCl salt
CAS#: 1448189-80-7
Chemical Formula: C22H30N4O3S
Exact Mass: 430.20
Molecular Weight: 430.600
Elemental Analysis: C, 61.37; H, 7.02; N, 13.01; O, 11.15; S, 7.45
Synonym: VHL Ligand 1 HCl salt
IUPAC/Chemical Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key: ZLOXMSNKPDWMEF-ZIFCJYIRSA-N
InChi Code: InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19-/m1/s1
SMILES Code: N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 430.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |