WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556157
CAS#: N/A
Description: Lipid A6 is an ionizable and biodegradable lipid. Lipid A6 has similar structure as Dlin-MC3-DMA but with ester and alkyne bonds to improve its biodegradability and cell membrane fusion ability. Lipid A6 forms lipid-like nanoparticles together with cKK-E12 synergistically to facilitate robust mRNA delivery with improved tolerability. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.
Hodoodo Cat#: H556157
Name: Lipid A6
CAS#: N/A
Chemical Formula: C43H75NO6
Exact Mass: 701.56
Molecular Weight: 702.074
Elemental Analysis: C, 73.56; H, 10.77; N, 2.00; O, 13.67
Synonym: Lipid A6; LipidA6; Lipid-A6
IUPAC/Chemical Name: di(dec-3-yn-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate
InChi Key: KBXFPWUGHXHAKA-UHFFFAOYSA-N
InChi Code: InChI=1S/C43H75NO6/c1-5-7-9-11-13-15-23-29-38-48-41(45)34-27-21-17-19-25-32-40(50-43(47)36-31-37-44(3)4)33-26-20-18-22-28-35-42(46)49-39-30-24-16-14-12-10-8-6-2/h40H,5-14,17-22,25-39H2,1-4H3
SMILES Code: CCCCCCC#CCCOC(CCCCCCCC(OC(CCCN(C)C)=O)CCCCCCCC(OCCC#CCCCCCC)=O)=O
Appearance: Liquid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 702.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |