WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122197
CAS#: 2414905-34-1
Description: Thalidomide-O-PEG5-Tosyl is a molecule that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. It is reactive with nucleophiles such as amine, hydroxy containing molecules.
Hodoodo Cat#: H122197
Name: Thalidomide-O-PEG5-Tosyl
CAS#: 2414905-34-1
Chemical Formula: C30H36N2O12S
Exact Mass: 648.20
Molecular Weight: 648.680
Elemental Analysis: C, 55.55; H, 5.59; N, 4.32; O, 29.60; S, 4.94
Synonym: Thalidomide-O-PEG5-Tosyl
IUPAC/Chemical Name: 4-((14-((di(l1-oxidanyl)(p-tolyl)-l4-sulfanyl)oxy)-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key: JMGZBYJZCMGZII-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H36N2O12S/c1-21-5-7-22(8-6-21)45(37,38)44-20-18-42-16-14-40-12-11-39-13-15-41-17-19-43-25-4-2-3-23-27(25)30(36)32(29(23)35)24-9-10-26(33)31-28(24)34/h2-8,24H,9-20H2,1H3,(H,31,33,34)
SMILES Code: O=C1NC(C(N2C(C(C(OCCOCCOCCOCCOCCOS([O])([O])C3=CC=C(C)C=C3)=CC=C4)=C4C2=O)=O)CC1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 648.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |