WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525469
CAS#: 71274-97-0
Description: LY 134046 is a centrally active inhibitor of phenylethanolamine-N-methyltransferase (PNMT).
Hodoodo Cat#: H525469
Name: LY 134046
CAS#: 71274-97-0
Chemical Formula: C10H12Cl3N
Exact Mass: 0.00
Molecular Weight: 252.570
Elemental Analysis: C, 47.55; H, 4.79; Cl, 42.11; N, 5.55
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Synonym: LY 134046; LY134046; LY-134046; Lilly 134046.
IUPAC/Chemical Name: 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride
InChi Key: QKYSZWIAKOJELI-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H11Cl2N.ClH/c11-9-4-3-7-2-1-5-13-6-8(7)10(9)12;/h3-4,13H,1-2,5-6H2;1H
SMILES Code: ClC1=C2C(CCCNC2)=CC=C1Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 252.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Durcan MJ, Lister RG, Linnoila M. Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol. Psychopharmacology (Berl). 1990;101(2):196-202. PubMed PMID: 2349361.
2: Sheaves R, Laynes R, MacKinnon P. Reduction of central epinephrine concentrations is consistent with the continued occurrence of ovulation in rats treated with an inhibitor (LY 134046) of phenylethanolamine N-methyltransferase. Neuroendocrinology. 1985 Nov;41(5):432-6. PubMed PMID: 3903538.