WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525479
CAS#: 92218-37-6
Description: LY 164846 is a new oral cephalosporin, effective against staphylococci, streptococci, Haemophilus influenzae, Branhamella catarrhalis, and Neisseria species.
Hodoodo Cat#: H525479
Name: LY 164846
CAS#: 92218-37-6
Chemical Formula: C18H17N3O4S2
Exact Mass: 403.07
Molecular Weight: 403.480
Elemental Analysis: C, 53.58; H, 4.25; N, 10.41; O, 15.86; S, 15.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: LY 164846; LY164846; LY-164846; 7-Bgmcc.
IUPAC/Chemical Name: 7-((Aminobenzo(b)thien-3-ylacetyl)amino)-3-methyl-3-cephem-4-carboxylic acid
InChi Key: UZIXWKQHCIOPLV-FVKWTLKZSA-N
InChi Code: InChI=1S/C18H17N3O4S2/c1-8-6-27-17-13(16(23)21(17)14(8)18(24)25)20-15(22)12(19)10-7-26-11-5-3-2-4-9(10)11/h2-5,7,12-13,17H,6,19H2,1H3,(H,20,22)(H,24,25)/t12?,13?,17-/m0/s1
SMILES Code: O=C1C(NC(C(N)C2=CSC3=CC=CC=C32)=O)[C@]4([H])SCC(C)=C(C(O)=O)N14
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 403.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sassine-Nawas G, Baker CN, Thornsberry C. Antimicrobial activity of LY164846, a new oral cephalosporin, and recommendations for disk diffusion tests. Diagn Microbiol Infect Dis. 1987 Jan;6(1):41-8. PubMed PMID: 3100126.
2: Jorgensen JH, Redding JS, Howell AW. Comparative activities of LY 164846 and other orally administered beta-lactam antibiotics against Haemophilus influenzae. Antimicrob Agents Chemother. 1986 Jun;29(6):1090-1. PubMed PMID: 3488021; PubMed Central PMCID: PMC180505.
3: Lauderdale BL, Yu PK, Washington JA 2nd. In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates. Antimicrob Agents Chemother. 1986 Apr;29(4):560-4. PubMed PMID: 3486628; PubMed Central PMCID: PMC180441.
4: Jones RN, Baker C, Barry AL, Fuchs PC. LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks. Antimicrob Agents Chemother. 1986 Mar;29(3):530-4. PubMed PMID: 3755018; PubMed Central PMCID: PMC180430.
5: Kukolja S, Pfeil JL, Draheim SE, Ott JL. Orally absorbable cephalosporin antibiotics. 3. Preparation of biologically active R isomer of 7-(3-benzothienylglycylamido)deacetoxycephalosporanic acid. J Med Chem. 1985 Dec;28(12):1903-6. PubMed PMID: 2933520.
6: Kukolja S, Draheim SE, Pfeil JL, Cooper RD, Graves BJ, Holmes RE, Neel DA, Huffman GW, Webber JA, Kinnick MD, et al. Orally absorbable cephalosporin antibiotics. 1. Structure-activity relationships of benzothienyl- and naphthylglycine derivatives of 7-aminodeacetoxycephalosporanic acid. J Med Chem. 1985 Dec;28(12):1886-96. PubMed PMID: 2933519.
