WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122390
CAS#: N/A
Description: D6808 is a poatnet c-Met inhibitor, D6808 potently inhibited c-Met kinase and MET-amplified Hs746T gastric cancer cells with IC50 values of 2.9 and 0.7 nM, respectively. It also strongly suppressed Ba/F3-Tpr-Met cells harboring resistance-relevant mutations (F1200L/M1250T/H1094Y/F1200I/L1195V) with IC50 values of 4.2, 3.2, 1.0, 39.0, and 33.4 nM, respectively. Furthermore, D6808 exhibited extraordinary target specificity in a Kinome profiling against 373 wild-type kinases and served as a promising macrocycle-based compound for further anticancer drug development
Hodoodo Cat#: H122390
Name: D6808
CAS#: N/A
Chemical Formula: C30H25F3N6O2
Exact Mass: 558.20
Molecular Weight: 558.570
Elemental Analysis: C, 64.51; H, 4.51; F, 10.20; N, 15.05; O, 5.73
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Synonym: D6808; D-6808; D 6808
IUPAC/Chemical Name: (14Z,52E)-63-(trifluoromethyl)-51,56-dihydro-11H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-56,7-dione
InChi Key: PQNIGFMNUHDZKX-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H25F3N6O2/c31-30(32,33)25-15-20-4-5-24(25)29(41)34-10-1-2-11-38-18-23(17-36-38)22-14-21-13-19(3-6-26(21)35-16-22)9-12-39-28(40)8-7-27(20)37-39/h3-8,13-18H,1-2,9-12H2,(H,34,41)
SMILES Code: O=C(C1=CC=C(C(C=C2)=NN(CCC3=CC4=CC5=CN=C4C=C3)C2=O)C=C1C(F)(F)F)NCCCCN6N=CC5=C6
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 558.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Wang C, Li J, Qu L, Tang X, Song X, Yang F, Chen X, Lin Q, Lin W, Zhou Y, Tu
Z, Chen Y, Zhang Z, Lu X. Discovery of D6808, a Highly Selective and Potent
Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene
Alteration Treatment. J Med Chem. 2022 Nov 24;65(22):15140-15164. doi:
10.1021/acs.jmedchem.2c00981. Epub 2022 Nov 10. PMID: 36355693.