WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122392
CAS#: 2375193-43-2
Description: XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression.
Hodoodo Cat#: H122392
Name: XRK3F2 HCl
CAS#: 2375193-43-2
Chemical Formula: C23H24ClF2NO3
Exact Mass: 435.14
Molecular Weight: 435.900
Elemental Analysis: C, 63.38; H, 5.55; Cl, 8.13; F, 8.72; N, 3.21; O, 11.01
Synonym: XRK3F2 HCl; XRK-3F2 HCl; XRK 3F2 HCl
IUPAC/Chemical Name: 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride
InChi Key: OKFZPRHMUQRCLJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H
SMILES Code: OCCNCC1=CC(OCC2=CC=C(F)C=C2)=C(OCC3=CC=C(F)C=C3)C=C1.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 435.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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PMC5615182.
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K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFβ2-induced epithelial to
mesenchymal transition of lens epithelial cells: selective acetylation of K56
and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. doi:
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