WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122430
CAS#: N/A
Description: A8B4 is a HDAC8 inhibitor.
Hodoodo Cat#: H122430
Name: A8B4
CAS#: N/A
Chemical Formula: C33H33N3O6
Exact Mass: 567.24
Molecular Weight: 567.640
Elemental Analysis: C, 69.83; H, 5.86; N, 7.40; O, 16.91
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Synonym: A8B-4; A8B 4; A8B4
IUPAC/Chemical Name: 3-(2-((E)-3-(((2S,E)-5,12-dioxo-2-phenyloxacyclododec-8-en-4-yl)methyl)benzylidene)hydrazine-1-carbonyl)-N-hydroxybenzamide
InChi Key: UWNXAZPZVNDDDF-DQHUSZGOSA-N
InChi Code: InChI=1S/C33H33N3O6/c37-29-16-6-1-2-7-17-31(38)42-30(25-12-4-3-5-13-25)21-28(29)19-23-10-8-11-24(18-23)22-34-35-32(39)26-14-9-15-27(20-26)33(40)36-41/h1-5,8-15,18,20,22,28,30,41H,6-7,16-17,19,21H2,(H,35,39)(H,36,40)/b2-1+,34-22+/t28?,30-/m0/s1
SMILES Code: O=C1C(CC2=CC=CC(/C=N/NC(C3=CC(C(NO)=O)=CC=C3)=O)=C2)C[C@H](OC(CC/C=C/CC1)=O)C4=CC=CC=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 567.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
@article{Gao2013SynthesisAC,
title={Synthesis and characterization of resorcinarene-centered amphiphilic A8B4 miktoarm star copolymers based on poly($\epsilon$-caprolactone) and poly(ethylene glycol) by combination of CROP and “click” chemistry},
author={Chen Gao and Ying Wang and Pengfei Gou and Xia Cai and Xiaodong Li and Weipu Zhu and Zhi-quan Shen},
journal={Journal of Polymer Science Part A},
year={2013},
volume={51},
pages={2824-2833}
}