GNE-987

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H122442

CAS#: 2417371-71-0

Description: GNE-987 is a BRD4 degrader.

Chemical Structure

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GNE-987
CAS# 2417371-71-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H122442
Name: GNE-987
CAS#: 2417371-71-0
Chemical Formula: C56H67F2N9O8S2
Exact Mass: 1,095.45
Molecular Weight: 1,096.320
Elemental Analysis: C, 61.35; H, 6.16; F, 3.47; N, 11.50; O, 11.67; S, 5.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GNE-987, GNE987, GNE 987

IUPAC/Chemical Name: 7-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide

InChi Key: VTPSYVSGGUUAFN-FOHMWQTKSA-N

InChi Code: InChI=1S/C56H67F2N9O8S2/c1-33-49(76-32-63-33)35-18-16-34(17-19-35)25-62-53(71)45-23-39(68)29-67(45)55(73)50(56(2,3)4)64-46(69)15-13-11-9-7-8-10-12-14-20-59-52(70)40-24-44-41(21-36(40)31-77(6,74)75)42-30-65(5)54(72)48-47(42)37(26-60-48)28-66(44)51-43(58)22-38(57)27-61-51/h16-19,21-22,24,26-27,30,32,39,45,50,60,68H,7-15,20,23,25,28-29,31H2,1-6H3,(H,59,70)(H,62,71)(H,64,69)/t39-,45+,50-/m0/s1

SMILES Code: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(CCCCCCCCCCNC(C4=C(CS(=O)(C)=O)C=C(C(N(C5=NC=C(F)C=C5F)C6)=C4)C7=CN(C)C(C8=C7C6=CN8)=O)=O)=O)=O)C[C@@H](O)C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,096.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sang X, Zhang Y, Fang F, Gao L, Tao Y, Li X, Zhang Z, Wang J, Tian Y, Li Z,
Yao D, Wu Y, Chu X, Zhang K, Ma L, Lu L, Chen Y, Yu J, Zhuo R, Wu S, Zhang Z,
Pan J, Hu S. BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting
Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. J Immunol Res. 2022
Aug 1;2022:7912484. doi: 10.1155/2022/7912484. PMID: 35958877; PMCID:
PMC9359861.

2: Sternicki LM, Nonomiya J, Liu M, Mulvihill MM, Quinn RJ. Native Mass
Spectrometry for the Study of PROTAC GNE-987-Containing Ternary Complexes.
ChemMedChem. 2021 Jul 20;16(14):2206-2210. doi: 10.1002/cmdc.202100113. Epub
2021 May 4. PMID: 33792163; PMCID: PMC8359942.

3: Pillow TH, Adhikari P, Blake RA, Chen J, Del Rosario G, Deshmukh G, Figueroa
I, Gascoigne KE, Kamath AV, Kaufman S, Kleinheinz T, Kozak KR, Latifi B, Leipold
DD, Sing Li C, Li R, Mulvihill MM, O'Donohue A, Rowntree RK, Sadowsky JD, Wai J,
Wang X, Wu C, Xu Z, Yao H, Yu SF, Zhang D, Zang R, Zhang H, Zhou H, Zhu X,
Dragovich PS. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo
Activity. ChemMedChem. 2020 Jan 7;15(1):17-25. doi: 10.1002/cmdc.201900497. Epub
2019 Nov 14. PMID: 31674143.

4: Fang F, Lu J, Sang X, Tao YF, Wang JW, Zhang ZM, Zhang YP, Li XL, Xie Y, Wu
SY, Chu XR, Li G, Wu D, Chen YL, Yu JJ, Jia SQ, Feng CX, Tian YY, Li ZH, Ling J,
Hu SY, Pan J. Super-enhancer profiling identifies novel critical and targetable
cancer survival gene LYL1 in pediatric acute myeloid leukemia. J Exp Clin Cancer
Res. 2022 Jul 16;41(1):225. doi: 10.1186/s13046-022-02428-9. PMID: 35842703;
PMCID: PMC9288051.