WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122510
CAS#: N/A
Description: TDI-8304 is a Pf20S inhibitor
Hodoodo Cat#: H122510
Name: TDI-8304
CAS#: N/A
Chemical Formula: C32H47N5O6
Exact Mass: 597.35
Molecular Weight: 597.760
Elemental Analysis: C, 64.30; H, 7.93; N, 11.72; O, 16.06
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Synonym: TDI8304; TDI-8304 ;TDI 8304
IUPAC/Chemical Name: (7S,10S,13S)-N-cyclopentyl-10-(2-morpholinoethyl)-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diaza-1(1,3)-benzenacyclotetradecaphane-7-carboxamide
InChi Key: UGEFECOTMZPOER-KCHLEUMXSA-N
InChi Code: InChI=1S/C32H47N5O6/c38-29-12-6-14-37(29)28-22-23-7-5-10-25(21-23)43-18-4-3-11-26(30(39)33-24-8-1-2-9-24)34-31(40)27(35-32(28)41)13-15-36-16-19-42-20-17-36/h5,7,10,21,24,26-28H,1-4,6,8-9,11-20,22H2,(H,33,39)(H,34,40)(H,35,41)/t26-,27-,28-/m0/s1
SMILES Code: O=C(N[C@@H](CCN1CCOCC1)C(N[C@@H]2C(NC3CCCC3)=O)=O)[C@H](CC4=CC(OCCCC2)=CC=C4)N5CCCC5=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 597.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Garg S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, Cooper RA, Rosenthal PJ. Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. Antimicrob Agents Chemother. 2022 Oct 18;66(10):e0081722. doi: 10.1128/aac.00817-22. Epub 2022 Sep 12. PMID: 36094216; PMCID: PMC9578402.