DH4

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H122519

CAS#: N/A

Description: DH4 is a SERT inhibitor with IC50 = 0.58 nM. DH4 was discovered with a bioavailability of 83.28% in rats by replacing the nonbioavailable substructure of approved drug vilazodone. DH4 exhibits promising antidepression efficacy in animal experiments.

Chemical Structure

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DH4
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H122519
Name: DH4
CAS#: N/A
Chemical Formula: C26H24F2N6
Exact Mass: 458.20
Molecular Weight: 458.520
Elemental Analysis: C, 68.11; H, 5.28; F, 8.29; N, 18.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DH4; DH 4; DH-4

IUPAC/Chemical Name: 3-(3-(4-(5-(2,4-difluorophenyl)pyrimidin-2-yl)piperazin-1-yl)propyl)-1H-indole-5-carbonitrile

InChi Key: MONCKXMZFAXBAZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H24F2N6/c27-21-4-5-22(24(28)13-21)20-16-31-26(32-17-20)34-10-8-33(9-11-34)7-1-2-19-15-30-25-6-3-18(14-29)12-23(19)25/h3-6,12-13,15-17,30H,1-2,7-11H2

SMILES Code: FC1=CC(F)=CC=C1C(C=N2)=CN=C2N(CC3)CCN3CCCC4=CNC5=CC=C(C#N)C=C54

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Wang ZZ, Yi C, Huang JJ, Xu TF, Chen KZ, Wang ZS, Xue YP, Lu JL, Nie B, Zhang YJ, Jin CF, Hao GF. Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter. J Med Chem. 2023 Jan 12;66(1):371-383. doi: 10.1021/acs.jmedchem.2c01339. Epub 2023 Jan 4. PMID: 36598095.