WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122520
CAS#: N/A
Description: OUL-232 is an inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15 at nM potencies. OUL232 showed PART10 inhibitory activity with IC50 = 7.8 nM.
Hodoodo Cat#: H122520
Name: OUL-232
CAS#: N/A
Chemical Formula: C10H10N4O2S
Exact Mass: 250.05
Molecular Weight: 250.280
Elemental Analysis: C, 47.99; H, 4.03; N, 22.39; O, 12.79; S, 12.81
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Synonym: OUL-232; OUL232; OUL 232
IUPAC/Chemical Name: 5,8-dimethoxybenzo[4,5]thiazolo[2,3-c][1,2,4]triazol-3-amine
InChi Key: FSNNMBVVDWKKCB-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H10N4O2S/c1-15-5-3-4-6(16-2)8-7(5)14-9(11)12-13-10(14)17-8/h3-4H,1-2H3,(H2,11,12)
SMILES Code: NC1=NN=C2SC3=C(OC)C=CC(OC)=C3N21
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 250.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Murthy S, Nizi MG, Maksimainen MM, Massari S, Alaviuhkola J, Lippok BE, Vagaggini C, Sowa ST, Galera-Prat A, Ashok Y, Venkannagari H, Prunskaite-Hyyryläinen R, Dreassi E, Lüscher B, Korn P, Tabarrini O, Lehtiö L. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4. doi: 10.1021/acs.jmedchem.2c01460. Epub ahead of print. PMID: 36598465.