WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122556
CAS#: 58-97-9
Description: Uridine 5'-monophosphate has been shown to have anticancer activity in vitro and in vivo, as well as antiviral activity against herpes viruses.
Hodoodo Cat#: H122556
Name: Uridine 5'-monophosphate
CAS#: 58-97-9
Chemical Formula: C9H13N2O9P
Exact Mass: 324.04
Molecular Weight: 324.180
Elemental Analysis: C, 33.35; H, 4.04; N, 8.64; O, 44.42; P, 9.55
Synonym: Uridine 5'-monophosphate; 5'-URIDYLIC ACID; Uridylic acid; 58-97-9; Uridine monophosphate
IUPAC/Chemical Name: ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChi Key: DJJCXFVJDGTHFX-XVFCMESISA-N
InChi Code: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
SMILES Code: O[C@@H]([C@H]([C@H](N1C(NC(C=C1)=O)=O)O2)O)[C@H]2COP(O)(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 324.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tsang WY, Wood BM, Wong FM, Wu W, Gerlt JA, Amyes TL, Richard JP. Proton
transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine
5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion
intermediate and the effect of a 5-fluoro substituent. J Am Chem Soc. 2012 Sep
5;134(35):14580-94. doi: 10.1021/ja3058474. Epub 2012 Aug 21. PMID: 22812629;
PMCID: PMC3434256.
2: Lomozik L, Jastrzab R. Copper(II) complexes with uridine, uridine
5'-monophosphate, spermidine, or spermine in aqueous solution. J Inorg Biochem.
2003 Jan 15;93(3-4):132-40. doi: 10.1016/s0162-0134(02)00567-6. PMID: 12576275.
3: Jyssum S. Pyrimidine 5'-nucleosidase in Neisseria meningitidis. An enzyme
specific for uridine 5'-monophosphate. APMIS. 1989 Apr;97(4):343-6. PMID:
2497755.