MAO-A/5-HT2AR Inhibitor I14

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Hodoodo CAT#: H130002

CAS#: N/A

Description: MAO-A/5-HT2AR Inhibitor I14 is a dual MAO-A and 5-HT2AR inhibitor with improved antidepressant activity. The MAO-A/5-HT2AR Inhibitor I14 has been found to be able to occupy the active cavity of 5-HT2AR and MAO-A with multiple hydrogen bonding forces and π–π stacking interaction. It has also led to a reduction in the expression of 5-HT2AR in the brain tissue of mice through the promotion of interstitial 5-HT levels, which ultimately increases the efficiency of the antidepressant effect.

Chemical Structure

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MAO-A/5-HT2AR Inhibitor I14
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130002
Name: MAO-A/5-HT2AR Inhibitor I14
CAS#: N/A
Chemical Formula: C31H30FN3O2
Exact Mass: 495.23
Molecular Weight: 495.600
Elemental Analysis: C, 75.13; H, 6.10; F, 3.83; N, 8.48; O, 6.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MAO-A/5-HT2AR Inhibitor I14; MAO-A/5-HT2AR Inhibitor-I14; MAO-A/5-HT2AR InhibitorI14; MAO-A/5-HT2AR-IN-I14;

IUPAC/Chemical Name: 5-((5-(4-(2-Fluorophenyl)piperazin-1-yl)pentyl)oxy)-7H-dibenzo[de,h]quinolin-7-one

InChi Key: QMLRYAOQDOORLC-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H30FN3O2/c32-27-10-4-5-11-28(27)35-17-15-34(16-18-35)14-6-1-7-19-37-23-20-22-12-13-33-30-24-8-2-3-9-25(24)31(36)26(21-23)29(22)30/h2-5,8-13,20-21H,1,6-7,14-19H2

SMILES Code: O=C(C1=CC=CC=C12)C3=CC(OCCCCCN4CCN(C5=CC=CC=C5F)CC4)=CC6=CC=NC2=C63

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 495.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Sun X, Li N, Zhong P, Chen L, Sun J. Development of MAO-A and 5-HT2AR Dual Inhibitors with Improved Antidepressant Activity. J Med Chem. 2022 Oct 13;65(19):13385-13400. doi: 10.1021/acs.jmedchem.2c01271. Epub 2022 Sep 29. PMID: 36173886.