WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130018
CAS#: 1378535-08-0
Description: This product was removed for commerical reason.
Hodoodo Cat#: H130018
Name: Alintegimod (removed)
CAS#: 1378535-08-0
Chemical Formula: C28H32N2O6S4
Exact Mass: 620.11
Molecular Weight: 620.810
Elemental Analysis: C, 54.17; H, 5.20; N, 4.51; O, 15.46; S, 20.66
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: Alintegimod; 7HP349;
IUPAC/Chemical Name: [ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{bis[(thiophen-2-yl)methyl]carbamate}
InChi Key: PSBCCRKKPBQYJK-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H32N2O6S4/c31-27(29(19-23-5-1-15-37-23)20-24-6-2-16-38-24)35-13-11-33-9-10-34-12-14-36-28(32)30(21-25-7-3-17-39-25)22-26-8-4-18-40-26/h1-8,15-18H,9-14,19-22H2
SMILES Code: O=C(OCCOCCOCCOC(N(CC1=CC=CS1)CC2=CC=CS2)=O)N(CC3=CC=CS3)CC4=CC=CS4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 620.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://www.onclive.com/view/fda-grants-fast-track-status-to-7hp349-for-pd-1-resistant-metastatic-melanoma
2. Alintegimod, also known as 7HP349, is an immunomodulator and functions by activating the integrin cell adhesion molecules: VLA-4 and LFA-1 which is vital for generating an immune response against solid tumors. Alintegimod has been shown to lead to the enhancement of anti-tumor activity.