DC-CPin734

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H122634

CAS#: N/A

Description: DC-CPin734 is a CBP/P300 BRD inhibitor.

Chemical Structure

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DC-CPin734
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H122634
Name: DC-CPin734
CAS#: N/A
Chemical Formula: C21H21N5O2
Exact Mass: 375.17
Molecular Weight: 375.430
Elemental Analysis: C, 67.18; H, 5.64; N, 18.65; O, 8.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DC-CPin734; DCCPin734; DC CPin734

IUPAC/Chemical Name: 6-(4-(1H-pyrazol-5-yl)benzamido)-N-methyl-3,4-dihydroquinoline-1(2H)-carboxamide

InChi Key: QHHJMGIXHASDOF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21N5O2/c1-22-21(28)26-12-2-3-16-13-17(8-9-19(16)26)24-20(27)15-6-4-14(5-7-15)18-10-11-23-25-18/h4-11,13H,2-3,12H2,1H3,(H,22,28)(H,23,25)(H,24,27)

SMILES Code: CNC(N1CCCC2=C1C=CC(NC(C3=CC=C(C4=CC=NN4)C=C3)=O)=C2)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 375.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Bi X, Chen Y, Sun Z, Lu W, Xu P, Lu T, Ding H, Zhang N, Jiang H, Chen K, Zhou B, Luo C. Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127480. doi: 10.1016/j.bmcl.2020.127480. Epub 2020 Aug 31. PMID: 32882416.

Yellapu, N.K., Ly, T., Sardiu, M.E. et al. Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer. BMC Cancer 22, 627 (2022).